{"id":"W4417022576","doi":"10.1038/s41598-025-30556-7","title":"Synergy between ciprofloxacin and temperate phages overcomes therapeutic limitations caused by lysogen formation","year":2025,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Bacteriophages and microbial interactions","field":"Environmental Science","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Cystic Fibrosis Canada","keywords":"Lysogen; Lysogenic cycle; Lytic cycle; Temperateness; Bacteriophage; Burkholderia; Ciprofloxacin; Phage therapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002215953,0.0003403643,0.0003776169,0.0001794282,0.0001058814,0.0002616068,0.000165851,0.0002202655,0.00128885],"category_scores_gemma":[0.0002530997,0.00008071763,0.0001816461,0.00009096845,0.0001811129,0.0002446834,0.0003001905,0.0004561229,0.0002586557],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001044707,"about_ca_system_score_gemma":0.0002223386,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002080245,"about_ca_topic_score_gemma":0.0006253234,"domain_scores_codex":[0.9997519,0.00006877414,0.00001917728,0.00004005268,0.00005906883,0.00006103228],"domain_scores_gemma":[0.9997739,0.00007927452,0.00005640518,0.00002463208,0.00001995806,0.00004592785],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001658495,0.00008682632,0.0002653752,0.00006876464,0.000005580104,0.00001980441,0.0000096799,0.00009430077,0.9949781,0.00004756805,0.00004073782,0.0042175],"study_design_scores_gemma":[0.0000163167,0.001827173,0.003647761,0.000008706076,0.0000161578,0.0001356904,0.00001765657,0.0005946382,0.992184,0.00002341037,0.00152407,0.000004357851],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918168,0.001754372,0.004596679,0.00009358647,0.00002926377,0.0000593006,0.00008772657,0.00007168328,0.001490494],"genre_scores_gemma":[0.9951225,0.0006188707,0.003136695,0.00003161712,0.00001780023,0.0000265694,0.00008395816,0.00001146569,0.0009505785],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00128885,"threshold_uncertainty_score":0.004311681,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01729793665566371,"score_gpt":0.2528950022558636,"score_spread":0.2355970656001999,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}