{"id":"W4417023500","doi":"10.1093/ecco-jcc/jjaf213","title":"Efficacy and safety of risankizumab in patients with moderately to severely active Crohn’s disease: interim results from the SEQUENCE open-label extension study","year":2025,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"AbbVie","keywords":"Interim; Sequence (biology); Interim analysis; Extension (predicate logic); Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006781715,0.001010007,0.001912291,0.0003056326,0.0003368078,0.0009051227,0.0004489573,0.0009678321,0.002981517],"category_scores_gemma":[0.003605393,0.0004266695,0.002552638,0.0002641157,0.0005104734,0.0009787948,0.0004514304,0.002076739,0.0007690218],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003929514,"about_ca_system_score_gemma":0.0009575434,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001838491,"about_ca_topic_score_gemma":0.0003452353,"domain_scores_codex":[0.9982911,0.001084844,0.0001289022,0.0001585424,0.000155506,0.0001811387],"domain_scores_gemma":[0.995955,0.00113007,0.001220675,0.0006500129,0.0003600526,0.0006841619],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9256339,0.0100172,0.01305908,0.0002878633,0.001303098,0.0001388902,0.0001430623,0.001154772,0.00659554,0.0001060643,0.001580125,0.03998056],"study_design_scores_gemma":[0.4359362,0.4806671,0.07104881,0.00007681579,0.002085757,0.0004127763,0.00006795553,0.001977199,0.003699802,0.0004111071,0.003564247,0.00005228809],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929356,0.001704276,0.0008421973,0.0003071478,0.00009683573,0.0009831833,0.001615777,0.00007187565,0.001442987],"genre_scores_gemma":[0.9902921,0.0005741329,0.001837443,0.0004832753,0.0001955527,0.001176008,0.004319265,0.00001859884,0.001103761],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006781715,"threshold_uncertainty_score":0.03586555,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01794031683562044,"score_gpt":0.2899905887213934,"score_spread":0.272050271885773,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}