{"id":"W4417023557","doi":"10.1002/mds.70147","title":"Delayed Disease Onset Report in <scp>UK</scp> Biobank: Implications for Prodromal Studies in Parkinson's Disease","year":2025,"lang":"en","type":"article","venue":"Movement Disorders","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; McGill University; Hôpital du Sacré-Cœur de Montréal; McGill University Health Centre; University of Toronto","funders":"Barts Charity; National Institutes of Health; Prothena; Biogen; Canadian Institutes of Health Research; Parkinson Canada; Teva Pharmaceutical Industries; National Institute for Health and Care Research; Jazz Pharmaceuticals; Regeneron Pharmaceuticals; Eli Lilly and Company; Michael J. Fox Foundation for Parkinson's Research","keywords":"Disease; Documentation; Movement disorders; Central nervous system disease; MEDLINE; Degenerative disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03952618,0.0002657492,0.0004934987,0.002769515,0.0008095699,0.002285597,0.001171122,0.0008532908,0.002391984],"category_scores_gemma":[0.142445,0.0003596416,0.0003019249,0.005414236,0.0007902303,0.001948767,0.002052278,0.0008716526,0.0004389738],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002077906,"about_ca_system_score_gemma":0.00197611,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.03293555,"about_ca_topic_score_gemma":0.03116567,"domain_scores_codex":[0.9694043,0.01911904,0.005081216,0.002560509,0.002882563,0.0009523207],"domain_scores_gemma":[0.7527758,0.1159653,0.09540252,0.01447435,0.01771981,0.003662189],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003355573,0.00002233217,0.9811689,0.000291209,0.00007179088,0.0001728669,0.001126057,0.0001594643,0.0001744165,0.0005770656,0.004443197,0.01145723],"study_design_scores_gemma":[0.00003419748,0.0001267003,0.9893428,0.0006409812,0.00006219993,0.0005252081,0.00105238,0.0008091897,0.000297835,0.0005507049,0.006534206,0.00002358035],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9586685,0.00637544,0.00402752,0.009965735,0.000450176,0.0002727083,0.01484788,0.0000724327,0.005319602],"genre_scores_gemma":[0.9883647,0.0009887487,0.004481026,0.001341749,0.0001747395,0.0003060641,0.003799468,0.00002763889,0.0005158615],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03952618,"threshold_uncertainty_score":0.2090369,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02804799210566803,"score_gpt":0.3325602854063656,"score_spread":0.3045122933006975,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}