{"id":"W4417026750","doi":"10.1021/acs.jproteome.5c00734","title":"Mitochondrial Metabolic Reprogramming along with NRF2/KEAP1-Mediated Antioxidant Mechanisms Drive Temozolomide Resistance in Glioblastoma Multiforme","year":2025,"lang":"en","type":"article","venue":"Journal of Proteome Research","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nutrition International; SKiN Health","funders":"University Grants Commission; Council of Scientific and Industrial Research, India","keywords":"Glutaminolysis; Temozolomide; Citric acid cycle; Glycolysis; Glutamine; Glutathione; Mitochondrion; Antioxidant; Oxidative stress; Oxidative phosphorylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009324164,0.0002086436,0.0002592974,0.0002153201,0.0001145076,0.0002181156,0.00009437609,0.0001643668,0.0005127669],"category_scores_gemma":[0.00008487488,0.00008082623,0.000166048,0.0001932087,0.0001313086,0.0001629154,0.0001464566,0.0002651013,0.00009401088],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002647886,"about_ca_system_score_gemma":0.0001620175,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001218542,"about_ca_topic_score_gemma":0.001728883,"domain_scores_codex":[0.9999514,0.000006540099,0.000003917551,0.00001106585,0.00001318345,0.000013866],"domain_scores_gemma":[0.9999619,0.000002401402,0.00001774384,0.000002740288,0.0000078883,0.000007399533],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002503238,0.00003091391,0.003289602,0.00005824376,0.00001886802,0.0001230812,0.00003723465,0.0001867739,0.9907391,0.0001235224,0.0001078748,0.005034402],"study_design_scores_gemma":[0.0000373647,0.000700956,0.1757776,0.00002300293,0.000099404,0.001068442,0.0002904379,0.004243507,0.8118035,0.0005355746,0.005398244,0.00002205407],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964864,0.001594776,0.001075229,0.0001036765,0.000009234426,0.0000108537,0.0003285406,0.00004142014,0.0003498441],"genre_scores_gemma":[0.9980593,0.0007133497,0.0005025967,0.00004747207,0.000001883394,0.00001048137,0.0002340493,0.000004575899,0.0004263178],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001218542,"threshold_uncertainty_score":0.002422929,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0220517746542717,"score_gpt":0.3395314175442717,"score_spread":0.31747964289,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}