{"id":"W4417031746","doi":"10.1038/s41587-025-02915-2","title":"In vivo gene editing of human hematopoietic stem and progenitor cells using envelope-engineered virus-like particles","year":2025,"lang":"en","type":"article","venue":"Nature Biotechnology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Haematopoiesis; Progenitor cell; In vivo; Genome editing; Stem cell; Transduction (biophysics)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000361105,0.0002547933,0.0001840003,0.0001413473,0.0001551119,0.0004394701,0.0002145892,0.0003104024,0.0007474747],"category_scores_gemma":[0.0001590995,0.0001728899,0.0002704049,0.00009455147,0.0002411649,0.0001623034,0.0002119646,0.0006158747,0.00020489],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001692072,"about_ca_system_score_gemma":0.0001952846,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004035806,"about_ca_topic_score_gemma":0.0003640227,"domain_scores_codex":[0.9998678,0.0000351966,0.00001129041,0.00002432804,0.00003628263,0.00002506876],"domain_scores_gemma":[0.9999121,0.00003670858,0.00001623829,0.00001574486,0.000005840263,0.00001330283],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006118468,0.00001597447,0.00005383852,0.000009115017,0.000003841115,0.00004049792,0.00002467692,0.0001421161,0.9982752,0.0004092886,0.00002297695,0.0009414069],"study_design_scores_gemma":[0.00001181322,0.00006004194,0.0002248059,0.000001210582,0.000007805919,0.0001044312,0.000006450557,0.0007468472,0.99762,0.00005424276,0.001160878,0.000001356082],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9651451,0.0005549742,0.0315266,0.00008977765,0.00005008906,0.00007407041,0.0001842234,0.0001446402,0.002230613],"genre_scores_gemma":[0.9899822,0.000224973,0.006714886,0.00002580425,0.000006788584,0.00002054239,0.0002195644,0.00005368607,0.00275155],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007474747,"threshold_uncertainty_score":0.002500534,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00985797919738187,"score_gpt":0.2858130275432703,"score_spread":0.2759550483458884,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}