{"id":"W4417031746","doi":"10.1038/s41587-025-02915-2","title":"In vivo gene editing of human hematopoietic stem and progenitor cells using envelope-engineered virus-like particles","year":2025,"lang":"en","type":"article","venue":"Nature Biotechnology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Haematopoiesis; Progenitor cell; In vivo; Genome editing; Stem cell; Transduction (biophysics)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002476141,0.000171443,0.000249298,0.0002786911,0.00006442841,0.00001116849,0.0002728829,0.001053008,0.000008880715],"category_scores_gemma":[0.00003625675,0.0001730036,0.00004733574,0.0003834193,0.0002170106,0.000004594513,0.0002280752,0.0004452449,8.473098e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003167054,"about_ca_system_score_gemma":0.00008623946,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001500869,"about_ca_topic_score_gemma":0.0001162848,"domain_scores_codex":[0.998795,0.00006377089,0.0002859949,0.0004063561,0.0001145856,0.0003342763],"domain_scores_gemma":[0.999406,0.00001531844,0.00007792823,0.0003961777,0.00006613346,0.00003841477],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001423046,0.00005664221,0.0003606337,0.00006803439,0.00005230881,0.000008861912,0.0000259872,0.00001874049,0.9980015,0.0002815349,0.0002436425,0.0007397921],"study_design_scores_gemma":[0.0005953666,0.0003804489,0.00003971031,0.00003388515,0.00001220952,0.00001109874,0.00009392151,0.0001146999,0.9965836,0.000187011,0.001813083,0.0001349863],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993826,0.005089976,0.0001531991,0.0003913721,0.000183185,0.0002865708,0.00002168838,0.00002713863,0.00002081563],"genre_scores_gemma":[0.998401,0.0001856094,0.001047105,0.0001390528,0.00008241238,0.00001849535,0.000005476824,0.0000217377,0.00009906724],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004904367,"threshold_uncertainty_score":0.8121765,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00985797919738187,"score_gpt":0.2858130275432703,"score_spread":0.2759550483458884,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}