{"id":"W4417034004","doi":"10.1038/s41467-025-65880-z","title":"Iron-catalyzed three-component amino(radio)fluorination of alkenes to unprotected β-(radio)fluoroamines","year":2025,"lang":"en","type":"article","venue":"Nature Communications","topic":"Fluorine in Organic Chemistry","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"Natural Sciences and Engineering Research Council of Canada; People's Government of Jilin Province; Natural Science Foundation of Guangdong Province; Azrieli Foundation; Ontario Research Foundation; Canada Foundation for Innovation; National Natural Science Foundation of China; Science, Technology and Innovation Commission of Shenzhen Municipality; Government of Canada; Canadian Institutes of Health Research; Natural Science Foundation of Jilin Province","keywords":"Alkene; Drug discovery; Reagent; Radiosynthesis; Aryl; Hydroxylamine; Positron emission tomography","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001941959,0.0003263683,0.0001363238,0.0001338977,0.0001092707,0.00009499258,0.000259381,0.0002988905,0.0007990827],"category_scores_gemma":[0.0001499297,0.00008723839,0.0001491089,0.0000877741,0.0001550335,0.000214014,0.0001791861,0.0002944727,0.0002350175],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002277654,"about_ca_system_score_gemma":0.0001706653,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004345186,"about_ca_topic_score_gemma":0.000866097,"domain_scores_codex":[0.9999124,0.0000149012,0.000005717071,0.00002294757,0.00001456973,0.00002952458],"domain_scores_gemma":[0.9999373,0.00001277673,0.0000230968,0.000008691346,0.000009714056,0.000008442784],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009045612,0.00002282994,0.00009087686,0.0001012691,0.000008157767,0.0001408967,0.00005619758,0.0001914556,0.9952843,0.0005101308,0.00008189349,0.0034216],"study_design_scores_gemma":[0.00001003128,0.0001866219,0.0003359983,0.000005681958,0.000006775251,0.0001679636,0.000008466884,0.000441961,0.9963998,0.00004814392,0.002383571,0.000005114779],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.963365,0.001648411,0.02798878,0.0001188298,0.00005004081,0.00009116589,0.0002106692,0.0001969484,0.006330069],"genre_scores_gemma":[0.9923189,0.0004732099,0.005576919,0.00002846888,0.000006646947,0.000018134,0.00009103875,0.00001457864,0.001472309],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007990827,"threshold_uncertainty_score":0.002673209,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05472394816250749,"score_gpt":0.4096997359800257,"score_spread":0.3549757878175182,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}