{"id":"W4417035747","doi":"10.1056/nejmoa2501510","title":"Trial of Pegcetacoplan in C3 Glomerulopathy and Immune-Complex MPGN","year":2025,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Fogarty International Center; Swedish Orphan Biovitrum; Apellis Pharmaceuticals","keywords":"Glomerulopathy; Proteinuria; Placebo; Disease; Glomerulonephritis; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009336274,0.0001115139,0.0006161529,0.0003608102,0.00003014024,0.000002835707,0.0001728606,0.00006119097,0.0005412789],"category_scores_gemma":[0.0004377037,0.0000771025,0.00005720674,0.0001574803,0.0001430185,0.00003949248,0.00004325353,0.0002042125,0.000002735914],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002306935,"about_ca_system_score_gemma":0.0001336122,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001891252,"about_ca_topic_score_gemma":0.00005618143,"domain_scores_codex":[0.9985599,0.0002649775,0.0008608825,0.00009712094,0.00006804095,0.0001490887],"domain_scores_gemma":[0.9989621,0.0004195694,0.0003663724,0.0001429601,0.00007594793,0.00003302485],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.1200047,0.0007527533,0.1069945,0.0004999563,0.001117305,0.0001791614,0.004047953,0.00001711568,0.4338019,0.003525123,0.06368557,0.2653741],"study_design_scores_gemma":[0.7519211,0.003243211,0.140559,0.001584589,0.0003040603,0.0004506778,0.001090936,0.000003709754,0.00295479,0.002319708,0.0954207,0.0001474491],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9756353,0.01773646,0.00008353006,0.002533829,0.001636265,0.0002223606,0.000006809835,0.000005427369,0.002139956],"genre_scores_gemma":[0.9987289,0.0003213402,0.00003160895,0.00009244133,0.0003100641,0.000001350409,0.00001084557,0.000004282226,0.0004991287],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6319165,"threshold_uncertainty_score":0.5926624,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01956893381250795,"score_gpt":0.2951439612228818,"score_spread":0.2755750274103738,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}