{"id":"W4417036506","doi":"10.1038/s42003-025-09169-3","title":"MicroRNA-mediated neuronal detargeting alters astrocyte cell fate conversion trajectories in vivo","year":2025,"lang":"en","type":"article","venue":"Communications Biology","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre; Occupational Cancer Research Centre; Sunnybrook Hospital; University of Toronto","funders":"Social Sciences and Humanities Research Council of Canada; Natural Sciences and Engineering Research Council of Canada; Government of Canada; Canadian Institutes of Health Research; Sunnybrook Research Institute","keywords":"Reprogramming; Oligodendrocyte; Transcription factor; Astrocyte; Glutamatergic; Population; Cell fate determination; OLIG2; Neural stem cell; GABAergic","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000133922,0.0002052412,0.000155162,0.0001570629,0.00009951741,0.000404319,0.0001578405,0.0002675764,0.001048732],"category_scores_gemma":[0.0001494382,0.0001908878,0.0002028914,0.00009723253,0.0001834094,0.0001788197,0.0001781795,0.0004891041,0.0003767047],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001784531,"about_ca_system_score_gemma":0.0001986568,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003646484,"about_ca_topic_score_gemma":0.0006453647,"domain_scores_codex":[0.9998538,0.00001312572,0.00001382918,0.00004791324,0.0000396395,0.0000316091],"domain_scores_gemma":[0.9999058,0.00001491944,0.00003514082,0.00001188212,0.00001154024,0.0000206978],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002724907,0.000008305229,0.00007259999,0.000008871225,0.00000189728,0.00001419538,0.00000845202,0.00006561128,0.9988768,0.00008533396,0.00001997898,0.0008107797],"study_design_scores_gemma":[0.000006422504,0.000104106,0.001084916,0.000002480308,0.000007609179,0.00006652359,0.00001304488,0.001680339,0.9958103,0.0000460792,0.001174695,0.000003559802],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9858323,0.0002823661,0.01134277,0.00005692547,0.00005094826,0.00003350327,0.0002817044,0.0002888285,0.001830544],"genre_scores_gemma":[0.9895851,0.0004274552,0.006399223,0.00004204031,0.000006222563,0.00005697924,0.0002756053,0.00009817509,0.003109106],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001048732,"threshold_uncertainty_score":0.003508389,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0161233894660057,"score_gpt":0.2851021782397262,"score_spread":0.2689787887737204,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}