{"id":"W4417039133","doi":"10.33549/physiolres.935659","title":"Oxidative Stress, Metabolic Impairment and Neuroinflammation are Associated With Target Organ Damage in SHRSP","year":2025,"lang":"en","type":"article","venue":"Physiological Research","topic":"Neurological Disease Mechanisms and Treatments","field":"Neuroscience","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Fondation Leducq; Akademie Věd České Republiky; European Commission; McGill University","keywords":"Neuroinflammation; NADPH oxidase; NOX4; Oxidative phosphorylation; Oxidative stress; Glial fibrillary acidic protein; Microglia; Astrocyte; Pathogenesis","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003063268,0.0001664662,0.0002683154,0.0001617882,0.0002389229,0.0000793493,0.0002356493,0.00007486853,0.0001347061],"category_scores_gemma":[0.003242486,0.0001013369,0.00003197956,0.0009729378,0.0002724198,0.0001273397,0.000325147,0.0004371238,0.00002082603],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004566563,"about_ca_system_score_gemma":0.00005482135,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001809261,"about_ca_topic_score_gemma":0.00001905262,"domain_scores_codex":[0.9970661,0.001146934,0.0001693274,0.0006631538,0.0004403397,0.0005141289],"domain_scores_gemma":[0.9987169,0.0007817684,0.00005701448,0.0002061556,0.00007907836,0.0001590776],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005498544,0.0020028,0.022873,0.00002818302,0.00002229666,0.0005189832,0.00006082091,0.0001539519,0.9542227,0.01893646,0.0001865336,0.0004444047],"study_design_scores_gemma":[0.0009462499,0.0007013176,0.809402,0.00004836474,0.00000687282,3.724508e-7,0.00005179069,0.001346522,0.1608426,0.02650108,0.00004565342,0.000107122],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997738,0.00004035654,0.00001189634,0.0008783389,0.00001754975,0.0006117062,0.00005292209,0.00005571868,0.0005934993],"genre_scores_gemma":[0.9991669,0.0001319557,0.00003013214,0.0003204793,0.000009853749,0.0001282059,0.00001484431,0.000007988575,0.0001896555],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7933801,"threshold_uncertainty_score":0.41324,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07812230734140967,"score_gpt":0.3547511007884749,"score_spread":0.2766287934470652,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}