{"id":"W4417040363","doi":"10.1186/s13287-025-04847-9","title":"Device encapsulated MSCs for adaptive secretome therapy to effectively target ischaemic heart injury","year":2025,"lang":"en","type":"article","venue":"Stem Cell Research & Therapy","topic":"Tissue Engineering and Regenerative Medicine","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Mesenchymal stem cell; Stem cell; Cardioprotection; Ischemia; Stem-cell therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001889366,0.0003321725,0.0006505268,0.0007407796,0.0002836534,0.00003530899,0.0002483422,0.0001972284,0.0001153013],"category_scores_gemma":[0.00006775165,0.0002413607,0.0001616811,0.001441203,0.0001576227,0.00006102359,0.00005536177,0.0007256574,0.00008382589],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002757894,"about_ca_system_score_gemma":0.0004555584,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000101629,"about_ca_topic_score_gemma":0.000002980739,"domain_scores_codex":[0.9971158,0.0004039613,0.0003308028,0.0006325718,0.0006785512,0.0008383221],"domain_scores_gemma":[0.9976486,0.0006777167,0.0000371024,0.0005102967,0.0007543422,0.0003719735],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00413043,0.0002646856,0.0004290078,0.0001519751,0.0003270851,0.00001552114,0.002073828,0.0001285988,0.9300084,0.0004626419,0.02605469,0.03595312],"study_design_scores_gemma":[0.004541863,0.005433034,0.002456044,0.0004006358,0.00001256244,0.000005382955,0.0006589004,0.0009451366,0.5817059,0.0001123247,0.4034912,0.00023707],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9481008,0.03250512,0.007603216,0.004593253,0.0005441244,0.005336659,0.00004450155,0.0002015896,0.00107075],"genre_scores_gemma":[0.9511726,0.001292993,0.001946407,0.0006066272,0.0004801145,0.000811344,0.00003345335,0.00008424437,0.04357219],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3774365,"threshold_uncertainty_score":0.9842404,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06864397158815212,"score_gpt":0.3942256433174803,"score_spread":0.3255816717293282,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}