{"id":"W4417041654","doi":"10.1182/hematology.2025000701","title":"The varieties of therapeutic experience: navigating treatment options for patients with PNH","year":2025,"lang":"en","type":"article","venue":"Hematology","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; McGill University; University of Toronto; Jewish General Hospital","funders":"","keywords":"Eculizumab; Paroxysmal nocturnal hemoglobinuria; Disease; Complement (music); Complement system; Transplantation; Stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004822726,0.00009669791,0.0002084215,0.00002342299,0.0003255433,0.000005816689,0.0001344714,0.00005601129,0.00006016047],"category_scores_gemma":[0.00003633056,0.00005587804,0.00005495974,0.0000687288,0.0002800409,0.0000189731,0.00003176376,0.00003780862,0.000007164158],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000257727,"about_ca_system_score_gemma":0.00005436457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002392827,"about_ca_topic_score_gemma":0.00002790288,"domain_scores_codex":[0.9993178,0.00009450006,0.0002373992,0.0001418158,0.00001730935,0.0001911752],"domain_scores_gemma":[0.9989136,0.0006343701,0.0001096939,0.0002400204,0.00009640045,0.000005918584],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"observational","study_design_scores_codex":[0.0006348391,0.0007218825,0.4813473,0.0001209064,0.0009378576,5.082019e-7,0.002619253,0.000007242492,0.002039549,0.5026378,0.001153308,0.007779578],"study_design_scores_gemma":[0.03541885,0.00825927,0.3654355,0.001337638,0.001651308,0.0001047331,0.04728837,0.0001020738,0.1914718,0.04955658,0.2979083,0.001465503],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918139,0.005312317,0.0008313271,0.0003574041,0.0004349154,0.0008706287,0.00004093235,0.00003590665,0.0003026988],"genre_scores_gemma":[0.9987166,0.00001948147,0.00009012094,0.00003648322,0.000002807439,0.0006124632,0.00005128515,0.000005218283,0.0004655288],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4530812,"threshold_uncertainty_score":0.2503849,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0142424934181375,"score_gpt":0.302944658875419,"score_spread":0.2887021654572815,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}