{"id":"W4417041654","doi":"10.1182/hematology.2025000701","title":"The varieties of therapeutic experience: navigating treatment options for patients with PNH","year":2025,"lang":"en","type":"article","venue":"Hematology","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; McGill University; University of Toronto; Jewish General Hospital","funders":"","keywords":"Eculizumab; Paroxysmal nocturnal hemoglobinuria; Disease; Complement (music); Complement system; Transplantation; Stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003482046,0.0003545094,0.0005482226,0.000495179,0.001604775,0.003377205,0.0006507129,0.001900024,0.003407144],"category_scores_gemma":[0.007396248,0.0001722431,0.0006946612,0.0004574315,0.001497106,0.00344463,0.00251991,0.005801649,0.0008309077],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001165889,"about_ca_system_score_gemma":0.001864088,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000700018,"about_ca_topic_score_gemma":0.002231896,"domain_scores_codex":[0.9978327,0.001251234,0.0001759816,0.0001264235,0.0003945658,0.0002191085],"domain_scores_gemma":[0.9977604,0.0009372393,0.0002364663,0.0000624648,0.0002592916,0.0007441044],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004429868,0.0003001023,0.01169547,0.001448684,0.0001712276,0.00897637,0.005503113,0.001074594,0.001783818,0.02976697,0.1659734,0.7728632],"study_design_scores_gemma":[0.0001034115,0.0007838469,0.004716262,0.004088579,0.0001813977,0.03580557,0.01025621,0.000672951,0.0007199723,0.04574767,0.8968062,0.0001179366],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.03300912,0.4621658,0.01200583,0.4151125,0.009081917,0.00007907194,0.000126965,0.0001987312,0.06822005],"genre_scores_gemma":[0.2846402,0.5135669,0.0295421,0.1373224,0.02037043,0.0001838064,0.0003123428,0.0001887658,0.01387308],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.003482046,"threshold_uncertainty_score":0.01841503,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0142424934181375,"score_gpt":0.302944658875419,"score_spread":0.2887021654572815,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}