{"id":"W4417043238","doi":"10.1093/ageing/afaf318.010","title":"Herpesvirus Exposure, Cognitive Decline and Alzheimer Disease in Older Adults: Insights from a Multi-Cohort Study Using a Novel Multiplex Sero-assay","year":2025,"lang":"en","type":"article","venue":"Age and Ageing","topic":"Cytomegalovirus and herpesvirus research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity College","funders":"","keywords":"Dementia; Herpes simplex virus; Cohort; Multiplex; Cohort study; Cognitive decline; Disease; Alzheimer's disease; Serology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00240123,0.0004849739,0.0003909546,0.0009800363,0.0005818215,0.001254189,0.0004381034,0.0005035268,0.0006463006],"category_scores_gemma":[0.00263357,0.000328918,0.0008946413,0.000971255,0.0002674884,0.0004389143,0.0008530624,0.0005835151,0.0001239319],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003030321,"about_ca_system_score_gemma":0.0002889313,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007792443,"about_ca_topic_score_gemma":0.00955045,"domain_scores_codex":[0.99922,0.0002733926,0.00007975513,0.0002341002,0.0001211511,0.00007147888],"domain_scores_gemma":[0.998202,0.00030948,0.0006573603,0.0003292318,0.0002850922,0.0002168137],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002980097,0.00005803954,0.9965128,0.00001865811,0.0004652574,0.00005551948,0.0001399712,0.00003694816,0.0008338893,0.00001785317,0.00009981486,0.001463228],"study_design_scores_gemma":[0.00001620678,0.0001863834,0.9984545,0.00001039733,0.0002466837,0.0001840894,0.0001732951,0.0002857913,0.0002080338,0.00003126511,0.0001960294,0.000007319264],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985072,0.0004724287,0.0003526566,0.00003241313,0.000007152029,0.00001549954,0.0004614303,0.000004275235,0.000147055],"genre_scores_gemma":[0.9987502,0.0002123095,0.0004561946,0.00003663608,0.00001388467,0.00002393946,0.0003676272,0.000002387203,0.0001367863],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007792443,"threshold_uncertainty_score":0.01549417,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03891534928607197,"score_gpt":0.335090994340064,"score_spread":0.296175645053992,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}