{"id":"W4417044153","doi":"10.51731/cjht.2025.1301","title":"Vanzacaftor-Tezacaftor-Deutivacaftor (Alyftrek)","year":2025,"lang":"","type":"article","venue":"Canadian Journal of Health Technologies","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Cystic fibrosis; Drug; Mutation; Cystic fibrosis transmembrane conductance regulator; Public health","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005149659,0.000170411,0.0002951079,0.0004920145,0.0002967898,0.0008716472,0.0004081867,0.0006749652,0.02425993],"category_scores_gemma":[0.001542064,0.0000897518,0.0003968683,0.0003109524,0.0003428892,0.0002901647,0.0003756359,0.0010116,0.006534209],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001579187,"about_ca_system_score_gemma":0.003140904,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02061994,"about_ca_topic_score_gemma":0.04096648,"domain_scores_codex":[0.9995777,0.00005237788,0.00002772118,0.00004536327,0.0002178318,0.00007897196],"domain_scores_gemma":[0.9995514,0.00007344953,0.00008274992,0.00002623659,0.0001205422,0.0001456405],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001990674,0.0002241131,0.002990137,0.0006715514,0.0000874363,0.0008079048,0.0000655503,0.0003163819,0.01504736,0.009567044,0.1765956,0.7916362],"study_design_scores_gemma":[0.001216427,0.0007646321,0.006945317,0.0004950084,0.00007061033,0.002364189,0.00004745352,0.000421352,0.006583776,0.001134273,0.9799341,0.00002292528],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"other","genre_gemma":"other","genre_scores_codex":[0.100319,0.2446445,0.01206557,0.04155711,0.004892874,0.001063218,0.01021959,0.003120037,0.5821182],"genre_scores_gemma":[0.6108726,0.08291391,0.01278292,0.01074036,0.001130173,0.0003330249,0.008040089,0.0002960864,0.2728908],"genre_candidate":"other","genre_consensus":"other","teacher_disagreement_score":0.02425993,"threshold_uncertainty_score":0.08115751,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02383383768169574,"score_gpt":0.3518872957391622,"score_spread":0.3280534580574665,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}