{"id":"W4417050768","doi":"10.3390/curroncol32120684","title":"Breast Cancer Therapy by Small-Molecule Reactivation of Mutant p53","year":2025,"lang":"en","type":"article","venue":"Current Oncology","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; University of Missouri; U.S. Department of Defense","keywords":"Suppressor; Breast cancer; Tumor suppressor gene; Mutant; Cell cycle checkpoint; DNA damage; Apoptosis; Cancer; Cell cycle","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001353489,0.0002306039,0.0002108396,0.0002082259,0.00008419612,0.0002043173,0.0001579171,0.0002515216,0.001089811],"category_scores_gemma":[0.00009925688,0.0000775302,0.0002328377,0.0001476142,0.0001264742,0.0001145854,0.000126835,0.0004268588,0.0002808759],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001565707,"about_ca_system_score_gemma":0.0001102023,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002082731,"about_ca_topic_score_gemma":0.0003672428,"domain_scores_codex":[0.9999344,0.00001997267,0.000004364897,0.000009602321,0.00001477894,0.00001673627],"domain_scores_gemma":[0.9999653,0.00001111239,0.000008973084,0.000006659727,0.000002838826,0.000005123799],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003775586,0.0002906705,0.0002297059,0.000164166,0.00002411307,0.0001984847,0.00003478208,0.0003884844,0.971822,0.0005024635,0.0003578782,0.02560973],"study_design_scores_gemma":[0.0001823889,0.003054796,0.001648564,0.00001610655,0.00005136113,0.0009073234,0.00001534474,0.001167977,0.9760073,0.0001370788,0.01680537,0.000006401528],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9475337,0.03473567,0.008151962,0.0004976852,0.0002201993,0.0003080775,0.0004122836,0.00034969,0.007790739],"genre_scores_gemma":[0.9831188,0.01015954,0.002777375,0.0001276587,0.00003215194,0.0001092149,0.0002569513,0.00001877614,0.00339958],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001089811,"threshold_uncertainty_score":0.003645778,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05182383292824384,"score_gpt":0.3821323279376097,"score_spread":0.3303084950093659,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}