{"id":"W4417050775","doi":"10.3390/curroncol32120680","title":"Patient-Derived Organoids as a Platform to Decipher and Overcome Radioresistance: From the Tumor Microenvironment to Radiosensitizer Discovery","year":2025,"lang":"en","type":"article","venue":"Current Oncology","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Natural Science Foundation of China","keywords":"Radiosensitizer; Radioresistance; Organoid; DECIPHER; Tumor microenvironment; Tumor immunology; Personalized medicine; In vivo","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001840667,0.0005881691,0.0007382133,0.0005952612,0.0003154441,0.001757114,0.0005615077,0.0007071091,0.002538415],"category_scores_gemma":[0.001159899,0.0003152204,0.0006277278,0.0003616487,0.000466121,0.0006835297,0.001051084,0.001413664,0.001495754],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004787379,"about_ca_system_score_gemma":0.0007331466,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004896144,"about_ca_topic_score_gemma":0.001111821,"domain_scores_codex":[0.9993999,0.0001731093,0.00004850336,0.0001271669,0.000202054,0.00004926243],"domain_scores_gemma":[0.9991129,0.0002042689,0.00009646494,0.0002978079,0.0001645122,0.0001240843],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004116707,0.0001388842,0.002932516,0.0005254669,0.00008623887,0.0004341314,0.0002481301,0.003386674,0.9483863,0.003524934,0.003305779,0.03661944],"study_design_scores_gemma":[0.0000374478,0.0005796825,0.003248308,0.000102693,0.000122446,0.001301897,0.0002321981,0.003853231,0.9229849,0.001604629,0.06587775,0.00005488164],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.3084178,0.01972774,0.6342692,0.002292397,0.0008514995,0.001759349,0.01328539,0.004261841,0.0151347],"genre_scores_gemma":[0.6825261,0.01184237,0.2812694,0.001213331,0.00007721813,0.00143446,0.01264679,0.0007573828,0.008232984],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.002538415,"threshold_uncertainty_score":0.009734511,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02678058061264502,"score_gpt":0.3284603055881457,"score_spread":0.3016797249755007,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}