{"id":"W4417055360","doi":"10.1158/2643-3230.bcd-25-0246","title":"Molecular Plasticity Results in Oncofetal Reprogramming and Therapeutic Vulnerabilities in Juvenile Myelomonocytic Leukemia","year":2025,"lang":"en","type":"article","venue":"Blood Cancer Discovery","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"AstraZeneca (Canada)","funders":"HCA International Foundation; Wellcome Trust; Nationales Centrum für Tumorerkrankungen Heidelberg; Wilhelm Sander-Stiftung; José Carreras Leukämie-Stiftung; Joachim Herz Stiftung; Deutsche Forschungsgemeinschaft; Deutsches Krebsforschungszentrum","keywords":"Juvenile myelomonocytic leukemia; Reprogramming; Fetus; Mutation; Gene; PTPN11; Leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004706617,0.0002380105,0.0005244915,0.000397738,0.00005332624,0.00007895102,0.0001484565,0.0001592093,0.000009615036],"category_scores_gemma":[0.0003855674,0.0002183596,0.00007809696,0.0007114952,0.0002354148,0.0001810056,0.0001734983,0.0006812283,0.000002189309],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001560338,"about_ca_system_score_gemma":0.002143937,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005196757,"about_ca_topic_score_gemma":0.002371463,"domain_scores_codex":[0.9977948,0.000135321,0.0005449528,0.0006723005,0.0003034502,0.0005491581],"domain_scores_gemma":[0.9990546,0.0003456547,0.00006955052,0.0003912098,0.00004833008,0.00009063293],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01792379,0.002231816,0.5974953,0.005147379,0.001648215,0.004790444,0.008174757,0.01056893,0.1081007,0.01068532,0.0008951116,0.2323382],"study_design_scores_gemma":[0.07501777,0.002093371,0.6703342,0.007547948,0.001218344,0.0002011131,0.00755328,0.01940781,0.2000541,0.007713479,0.007028118,0.001830504],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899765,0.005198139,0.0001000046,0.001325074,0.0000960699,0.0006866052,0.00003110231,0.00004237784,0.002544109],"genre_scores_gemma":[0.9970039,0.0004357786,0.0002271335,0.0004914486,0.00006183451,0.0002773832,0.0000139698,0.00002724345,0.001461348],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2305077,"threshold_uncertainty_score":0.8904447,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01672271983316454,"score_gpt":0.30993910152471,"score_spread":0.2932163816915455,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}