{"id":"W4417055360","doi":"10.1158/2643-3230.bcd-25-0246","title":"Molecular Plasticity Results in Oncofetal Reprogramming and Therapeutic Vulnerabilities in Juvenile Myelomonocytic Leukemia","year":2025,"lang":"en","type":"article","venue":"Blood Cancer Discovery","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"AstraZeneca (Canada)","funders":"HCA International Foundation; Wellcome Trust; Nationales Centrum für Tumorerkrankungen Heidelberg; Wilhelm Sander-Stiftung; José Carreras Leukämie-Stiftung; Joachim Herz Stiftung; Deutsche Forschungsgemeinschaft; Deutsches Krebsforschungszentrum","keywords":"Juvenile myelomonocytic leukemia; Reprogramming; Fetus; Mutation; Gene; PTPN11; Leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005899461,0.0002460967,0.0002086233,0.0002501791,0.0002551305,0.0005967179,0.0002728428,0.0009687339,0.001110646],"category_scores_gemma":[0.0005056715,0.0001037736,0.000188058,0.0001902342,0.0007253714,0.0005040406,0.0004462345,0.002729574,0.0004318113],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007778287,"about_ca_system_score_gemma":0.0002922771,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000295417,"about_ca_topic_score_gemma":0.001258233,"domain_scores_codex":[0.9997546,0.00005011987,0.0000148444,0.00004641988,0.00009671376,0.00003725158],"domain_scores_gemma":[0.9998079,0.00009591721,0.00002050282,0.00001150037,0.00003549275,0.00002871121],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007538556,0.0001560107,0.002701696,0.0007835304,0.00006969986,0.003324968,0.0003281359,0.0006333521,0.3287026,0.05815148,0.2367664,0.3676283],"study_design_scores_gemma":[0.0001029737,0.0004149185,0.006842745,0.0002151386,0.00007309289,0.004331158,0.0002089772,0.0008958761,0.09699807,0.01411818,0.8757608,0.00003805087],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.1721073,0.4630403,0.01318585,0.2707521,0.02557063,0.0001614823,0.0009145408,0.001243082,0.05302474],"genre_scores_gemma":[0.5265089,0.2933819,0.004285266,0.08509371,0.01986358,0.0001704778,0.0004904455,0.000173966,0.07003175],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.001110646,"threshold_uncertainty_score":0.005643547,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01672271983316454,"score_gpt":0.30993910152471,"score_spread":0.2932163816915455,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}