{"id":"W4417062080","doi":"10.1200/po-25-00279","title":"Clinical Utility of Multicancer Detection in Symptomatic Patients: A Decision-Making Perspective","year":2025,"lang":"en","type":"article","venue":"JCO Precision Oncology","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"","keywords":"Perspective (graphical); Referral; Retraining; MEDLINE; Clinical judgment","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007586343,0.0001250181,0.0003156081,0.0001889841,0.00004707609,0.000006549782,0.0002278495,0.0003723606,0.00007605083],"category_scores_gemma":[0.003759396,0.0001202796,0.0001280532,0.0003384381,0.0001739692,0.000006355405,0.0002238977,0.0001901385,0.000006883187],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003898763,"about_ca_system_score_gemma":0.0004997278,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003302047,"about_ca_topic_score_gemma":0.0007487487,"domain_scores_codex":[0.9981102,0.0003284778,0.0007362277,0.0004982919,0.0001489446,0.0001778373],"domain_scores_gemma":[0.9981795,0.0006839207,0.0002161057,0.0004392038,0.0004480561,0.00003321419],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.001116662,0.0006862296,0.07375321,0.00001753033,0.00007097456,0.000001251199,0.0002168195,0.0001867884,0.00328469,0.0000899868,0.00110136,0.9194745],"study_design_scores_gemma":[0.004291446,0.001316605,0.9428836,0.0002789658,0.00006121796,0.00000319765,0.0008230005,0.005737085,0.01267439,0.009179392,0.02248857,0.0002625152],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9640265,0.0003747184,0.02920681,0.00009615525,0.001107932,0.0004554648,0.00001153333,0.00001007721,0.004710796],"genre_scores_gemma":[0.9916647,0.0001265658,0.007751756,0.000237051,0.00006337817,0.00007957804,0.000005320212,0.00001040552,0.00006124221],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.919212,"threshold_uncertainty_score":0.4904859,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01452539719696035,"score_gpt":0.4011360747315419,"score_spread":0.3866106775345816,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}