{"id":"W4417065318","doi":"10.1084/jem.20250025","title":"Chimeric MHC class I– and II–restricted non-self epitopes broaden antitumor T cell reactions","year":2025,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill Genome Centre; McGill University Health Centre","funders":"Kyoto University; Japan Society for the Promotion of Science; Meiji Seika Pharma","keywords":"T cell; Epitope; Antigen; Immune system; Cytotoxic T cell; Major histocompatibility complex; MHC class I; Cell; Antigen presentation; MHC class II","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001752698,0.0003229706,0.0003261073,0.000141206,0.00006669255,0.0002062142,0.0001098671,0.0002444408,0.001063892],"category_scores_gemma":[0.0001004835,0.0001140246,0.0002187612,0.0000865929,0.0001819446,0.000159731,0.0001995257,0.0006465908,0.0002046942],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001287093,"about_ca_system_score_gemma":0.0001402389,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006869563,"about_ca_topic_score_gemma":0.0001352661,"domain_scores_codex":[0.9998838,0.00002124243,0.000008281893,0.00002548732,0.00002224738,0.00003896152],"domain_scores_gemma":[0.9999094,0.00002581169,0.00001776031,0.00001377729,0.000007043924,0.00002617659],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000769543,0.00003755453,0.0001049933,0.00001701882,0.00000308326,0.00001660513,0.000005407091,0.0001126915,0.9982961,0.00005996631,0.00001351218,0.001256089],"study_design_scores_gemma":[0.00007696167,0.002249331,0.003463152,0.00001026103,0.00003477278,0.0005592422,0.00002452645,0.002379596,0.9890931,0.0001199914,0.001984001,0.000005042817],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971694,0.000630161,0.001396496,0.00002755054,0.00001367209,0.00002241931,0.00003368582,0.00003514381,0.0006715571],"genre_scores_gemma":[0.9982941,0.0002104516,0.000897362,0.00003439328,0.00001037329,0.00001255484,0.00004487296,0.000005740682,0.000490205],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001063892,"threshold_uncertainty_score":0.003559053,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007395131108109554,"score_gpt":0.2663774254395162,"score_spread":0.2589822943314066,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}