{"id":"W4417068346","doi":"10.7150/ijbs.123740","title":"Disrupted astrocyte-neuron glutamine-glutamate cycling in the medial prefrontal cortex contributes to depression-like behaviors","year":2025,"lang":"en","type":"article","venue":"International Journal of Biological Sciences","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"Ministry of Science and ICT, South Korea; Gyeongsang National University; National Research Foundation","keywords":"Prefrontal cortex; Conditional gene knockout; Glutamatergic; Glutamate receptor; Homeostasis; Glutamine; Glutamine synthetase; Phenotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006895389,0.0001182852,0.0001747856,0.0002593903,0.0001425318,0.0001744129,0.001600838,0.00006159773,0.00004037434],"category_scores_gemma":[0.001916416,0.00006121826,0.00009917984,0.0004900522,0.0004175162,0.0001860951,0.00018591,0.0002352996,0.000007112412],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005359765,"about_ca_system_score_gemma":0.00007304487,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001799538,"about_ca_topic_score_gemma":0.00003704589,"domain_scores_codex":[0.9981925,0.0002279316,0.0004626695,0.000277077,0.0005903156,0.0002495142],"domain_scores_gemma":[0.9986688,0.0009237913,0.0002000697,0.00006831911,0.00007880694,0.00006016383],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003900367,0.0003348684,0.1092801,0.000001417914,0.000008552516,0.0001570184,0.0002638755,0.0002958046,0.8735859,0.001634926,0.0003313645,0.01371615],"study_design_scores_gemma":[0.001038726,0.0003709223,0.9402397,0.0001191182,0.000006452527,0.00008644256,0.0006140589,0.0003027368,0.05247664,0.002325192,0.002289086,0.000130965],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930001,0.0001083363,0.0005898274,0.003885681,0.001575176,0.0001443284,0.00001340817,0.00001239881,0.0006706858],"genre_scores_gemma":[0.9968308,0.00005975779,0.0001576723,0.002830652,0.00008447157,0.000006851776,9.787101e-7,0.000001915082,0.0000268914],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8309596,"threshold_uncertainty_score":0.2974782,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03220452510976767,"score_gpt":0.3398937118497667,"score_spread":0.307689186739999,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}