{"id":"W4417070017","doi":"10.1093/jncics/pkaf114","title":"Tumor characteristics impact prognosis in deficient mismatch repair/microsatellite instability-high localized colorectal cancer—a systematic review and meta-analysis","year":2025,"lang":"en","type":"review","venue":"JNCI Cancer Spectrum","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"P. Carl Petersens Fond","keywords":"Colorectal cancer; KRAS; Overall survival; MEDLINE; Molecular biomarkers; Precision medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","metaepi_broad"],"consensus_categories":["metaepi_narrow"],"category_scores_codex":[0.0007922025,0.001378723,0.02071879,0.0007299182,0.0001620935,0.00009097093,0.0002722543,0.0002624372,0.0007617526],"category_scores_gemma":[0.0002509324,0.0008296758,0.005248488,0.003378374,0.0001827052,0.0000710714,0.0002454401,0.0006558296,0.000008352947],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00372187,"about_ca_system_score_gemma":0.001793884,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006271558,"about_ca_topic_score_gemma":0.003885869,"domain_scores_codex":[0.9939011,0.0005280105,0.002620672,0.001508898,0.0006039161,0.0008374398],"domain_scores_gemma":[0.9969222,0.000354701,0.001380302,0.0008463095,0.0002243883,0.0002721273],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.000105445,0.0003131873,0.001414927,0.8204039,0.1746721,0.0001630031,0.0001177102,7.634383e-7,1.221829e-7,0.00001419534,0.0001319351,0.00266268],"study_design_scores_gemma":[0.0004801759,0.0003325852,0.001557194,0.1241673,0.8650932,0.00005068085,0.00001981406,0.00001026607,0.000003803588,0.000006563987,0.007628255,0.0006501412],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0009430777,0.9841394,0.000002157719,0.0005601001,0.0001975816,0.01121636,0.002722382,0.0001274238,0.00009147465],"genre_scores_gemma":[0.002483152,0.9823045,0.00004647868,0.0004634241,0.00006264204,0.01371836,0.0003126588,0.00007702383,0.000531767],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.6962367,"threshold_uncertainty_score":0.9998963,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04161223833541557,"score_gpt":0.3702611330396836,"score_spread":0.328648894704268,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}