{"id":"W4417076454","doi":"10.1084/jem.20251760","title":"Autoantibodies neutralizing type I IFNs in patients with fulminant herpes simplex virus hepatitis","year":2025,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Liver Diseases and Immunity","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University Hospital Foundation","funders":"Fondation pour la Recherche Médicale; Fondation du Souffle; Institut National de la Santé et de la Recherche Médicale; CHIST-ERA; National Center for Advancing Translational Sciences; Agence Nationale de la Recherche; Ministère de l'Enseignement supérieur, de la Recherche et de l'Innovation; Science for Life Laboratory; Ministero della Salute; Institut des maladies génétiques Imagine; Fondazione IRCCS Policlinico San Matteo; St. Giles Foundation","keywords":"Autoantibody; Fulminant; Fulminant hepatitis; Hepatitis C virus; Hepatitis; Herpes simplex virus; Virus; Hepatitis B","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005715594,0.0003272628,0.0004042203,0.0006720393,0.0004510087,0.0005927012,0.0002420364,0.0005528205,0.001995321],"category_scores_gemma":[0.00361134,0.000278818,0.000364973,0.0006451455,0.0003767341,0.0005733466,0.0003772597,0.0007151275,0.0002644942],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001859424,"about_ca_system_score_gemma":0.0002096757,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001045712,"about_ca_topic_score_gemma":0.0007996064,"domain_scores_codex":[0.9994992,0.000171484,0.00006113743,0.00009449917,0.00007798201,0.00009580715],"domain_scores_gemma":[0.9981186,0.0006710035,0.0007758182,0.00009910133,0.00007743831,0.0002580081],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001447873,0.00001368281,0.9974965,0.000006622947,0.00001283798,0.0006080767,0.00004499672,0.00001801281,0.0001562168,0.0000159166,0.00004154806,0.00144088],"study_design_scores_gemma":[0.00002476436,0.0002629159,0.9884521,0.0000275793,0.00005068742,0.00996043,0.000335958,0.0002794436,0.0001890558,0.0001158584,0.0002941094,0.000007028421],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984907,0.0007477275,0.00009428011,0.0000709887,0.0000113943,0.000004527258,0.00003993118,0.000005427619,0.0005348904],"genre_scores_gemma":[0.9997147,0.0001422411,0.00003491285,0.00001827725,0.00001707204,0.000001452955,0.00003187166,8.309109e-7,0.00003876988],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001995321,"threshold_uncertainty_score":0.006675005,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01283159392305577,"score_gpt":0.3028377154342966,"score_spread":0.2900061215112408,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}