{"id":"W4417078467","doi":"10.1007/s40265-025-02263-0","title":"Safety and Tolerability of Glucagon-Like Peptide-1 Receptor Agonists: A State-of-the-Art Narrative Review","year":2025,"lang":"en","type":"article","venue":"Drugs","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba; St. Boniface Hospital","funders":"","keywords":"Tolerability; Discontinuation; Adverse effect; Pharmacovigilance; Clinical trial; Randomized controlled trial; Narrative review; Acute kidney injury","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002978162,0.0001105627,0.0004396111,0.00003500235,0.00004243192,0.000003936857,0.00007148395,0.00002071078,0.0000988003],"category_scores_gemma":[0.00008325763,0.00007394912,0.0001050114,0.0002337427,0.0001416267,0.00003812422,0.00009761287,0.00006484702,0.000007897726],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000672359,"about_ca_system_score_gemma":0.00007280084,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002167038,"about_ca_topic_score_gemma":0.00001056357,"domain_scores_codex":[0.9991331,0.00006062814,0.0003537109,0.0001858856,0.000148899,0.0001178489],"domain_scores_gemma":[0.9993189,0.0000643706,0.0001237314,0.0003570672,0.00009788635,0.00003802091],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001196055,0.002023127,0.05068992,0.02984236,0.002392064,0.000004767329,0.01476658,0.00000397187,0.001999804,0.005241748,0.449768,0.4420716],"study_design_scores_gemma":[0.002407626,0.000318675,0.02809741,0.007458793,0.0006561191,4.937538e-7,0.0009061845,0.00001742805,0.006278218,0.0005758804,0.9531304,0.0001527638],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8257742,0.03042707,0.00009282547,0.02443659,0.0007555654,0.004324219,0.00008080238,0.0000705758,0.1140381],"genre_scores_gemma":[0.842315,0.02328252,0.001467077,0.005829812,0.00003423854,0.000158279,0.0001240022,0.00002763479,0.1267615],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5033624,"threshold_uncertainty_score":0.3015558,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006647036455436086,"score_gpt":0.2643592821297305,"score_spread":0.2577122456742945,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}