{"id":"W4417082039","doi":"10.1007/s11357-025-02036-3","title":"Longitudinal effects of cerebrovascular reactivity and cerebral pulsatility in cognitively intact older adults with APOE4: links with cognition","year":2025,"lang":"en","type":"article","venue":"GeroScience","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Douglas Mental Health University Institute; Université du Québec à Montréal; Université de Montréal; Concordia University; Montreal Neurological Institute and Hospital; Montreal Heart Institute","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Fondation Brain Canada; Heart and Stroke Foundation of Canada; National Institutes of Health; Alzheimer's Association","keywords":"Middle cerebral artery; Apolipoprotein E; Cerebral arteries; Cognition; Posterior cerebral artery; Anterior cerebral artery; Effects of sleep deprivation on cognitive performance; Magnetic resonance imaging; Vascular disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009715771,0.0004635403,0.0003588399,0.0005791625,0.0005145643,0.000939845,0.000361497,0.0008530811,0.001269112],"category_scores_gemma":[0.002679064,0.0003455123,0.0006495871,0.0007804857,0.0003093392,0.000704361,0.0005415925,0.001019554,0.0002569741],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002664451,"about_ca_system_score_gemma":0.0003511032,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008772124,"about_ca_topic_score_gemma":0.009798133,"domain_scores_codex":[0.9997216,0.0000714519,0.00003018044,0.00006918874,0.00003884809,0.00006877999],"domain_scores_gemma":[0.9989178,0.0002505814,0.0003606401,0.0001234259,0.0001438546,0.0002036538],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001020551,0.0002343288,0.9949057,0.00001181072,0.000259512,0.0002188777,0.0002606231,0.00006644441,0.0007118207,0.0000383179,0.00006544305,0.00220656],"study_design_scores_gemma":[0.000004639617,0.0001204348,0.9994254,0.000002251069,0.00004995932,0.00006341226,0.0001147046,0.00008334582,0.00004518384,0.00003658035,0.00005034357,0.000003630054],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989979,0.0003478315,0.00006701966,0.00003619769,0.000008851502,0.000003906276,0.0001398101,0.000003612804,0.0003949575],"genre_scores_gemma":[0.9991907,0.0001268263,0.00007346555,0.00002845491,0.00001426835,0.000005947178,0.0001826985,0.000001780151,0.0003757322],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008772124,"threshold_uncertainty_score":0.01744217,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007051467884155951,"score_gpt":0.2708385726102594,"score_spread":0.2637871047261034,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}