{"id":"W4417088106","doi":"10.1038/s41598-025-31613-x","title":"Clinical validation of new alzheimer disease diagnosis tools based on plasma p-Tau217","year":2025,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Instituto de Salud Carlos III; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Ministerio de Ciencia e Innovación; Northern California Institute for Research and Education; Pfizer; Novartis Pharmaceuticals Corporation; Biogen; Eli Lilly and Company; Bristol-Myers Squibb; BioClinica; European Commission; U.S. Department of Defense; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; National Institute on Aging; Alzheimer's Association","keywords":"Cohort; Neuroimaging; Cohort study; Disease; Alzheimer's disease; Multivariate analysis; Multivariate statistics; Cognitive impairment","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006033305,0.001186358,0.0008823288,0.001801607,0.0005175299,0.001569598,0.0007809235,0.0007965488,0.0009155056],"category_scores_gemma":[0.01144331,0.0003236407,0.0007912837,0.0007710364,0.000502706,0.0005662531,0.001167861,0.000612488,0.0006624275],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004120822,"about_ca_system_score_gemma":0.0006213378,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002066755,"about_ca_topic_score_gemma":0.00229416,"domain_scores_codex":[0.9971276,0.001074473,0.0002666553,0.0006875201,0.0006432231,0.0002006438],"domain_scores_gemma":[0.9963629,0.001402721,0.0006994073,0.0004422358,0.0008339666,0.0002588739],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001650533,0.0001623164,0.9792876,0.00008960115,0.0004109627,0.0002300081,0.0002714862,0.0009275311,0.002091205,0.0001019046,0.0005592952,0.01421751],"study_design_scores_gemma":[0.0001206328,0.0008263362,0.986774,0.00007659102,0.0002647226,0.001029528,0.0002742803,0.005629491,0.002727081,0.0003989431,0.001841138,0.00003723503],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926732,0.001455428,0.003109401,0.0001059308,0.0000604102,0.0001074243,0.001100854,0.0000510577,0.001336305],"genre_scores_gemma":[0.9945754,0.0003907546,0.002412514,0.00005039397,0.00004580225,0.00008044336,0.002021879,0.0000163281,0.000406585],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006033305,"threshold_uncertainty_score":0.0319075,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07643346532041291,"score_gpt":0.40616135913998,"score_spread":0.3297278938195671,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}