{"id":"W4417089432","doi":"10.1038/s41467-025-67174-w","title":"Highly replicating hepatitis C virus variants emerge in immunosuppressed patients causing severe disease","year":2025,"lang":"en","type":"article","venue":"Nature Communications","topic":"Hepatitis C virus research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; Université de Montréal","funders":"Instituto de Salud Carlos III; Canadian Institutes of Health Research; Deutsche Forschungsgemeinschaft; National Institutes of Health; Generalitat de Catalunya; Government of Canada; Centres de Recerca de Catalunya; National Institute of Allergy and Infectious Diseases; European Commission; Deutsches Zentrum für Infektionsforschung; Foundation for the National Institutes of Health","keywords":"Hepatitis C virus; Viral replication; Hepatocellular carcinoma; Viral quasispecies; Genome; Virus; Viral evolution; Phenotype; Liver disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001642163,0.0001837254,0.0002764559,0.0004575725,0.0003409052,0.0004444698,0.0001124925,0.0003396707,0.001491191],"category_scores_gemma":[0.0008496605,0.0001326553,0.0001415895,0.0003227028,0.0002687689,0.0002127463,0.0003504164,0.0003818019,0.0002333585],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007890678,"about_ca_system_score_gemma":0.00009046999,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002293925,"about_ca_topic_score_gemma":0.0002696982,"domain_scores_codex":[0.9998603,0.00002687835,0.00001518796,0.00004191059,0.00002365057,0.00003214151],"domain_scores_gemma":[0.999411,0.0001311728,0.0002542768,0.00004876377,0.00002889789,0.0001259251],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009298435,0.00007233001,0.9077947,0.00003969826,0.0000475714,0.002469175,0.0003244854,0.0001300476,0.07472306,0.0001666552,0.000188427,0.01311413],"study_design_scores_gemma":[0.00001205208,0.0003615937,0.987104,0.000007466083,0.00003032653,0.006110683,0.000307208,0.0003275097,0.00503873,0.0001745018,0.0005170782,0.000008866126],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999534,0.0001331918,0.00008522764,0.00001665744,0.000002399779,0.000002501096,0.00002552312,0.000005191597,0.0001954282],"genre_scores_gemma":[0.9996595,0.00005277308,0.0001061604,0.00002476554,0.0000107509,0.000001672335,0.00005686768,0.000002495044,0.00008502587],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001491191,"threshold_uncertainty_score":0.004988551,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02145498934212432,"score_gpt":0.353558398369391,"score_spread":0.3321034090272666,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}