{"id":"W4417102757","doi":"10.3389/fimmu.2025.1722596","title":"Enhancing functional antibody responses against HIV envelope V1V2 through vaccine formulations","year":2025,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"National Institutes of Health; National Institute of Allergy and Infectious Diseases; U.S. Department of Veterans Affairs","keywords":"Antibody response; Human immunodeficiency virus (HIV); Antibody; HIV vaccine; AIDS Vaccines; Immune system; Envelope (radar)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002339899,0.0006143709,0.0002196638,0.000257469,0.00007436877,0.0002635279,0.0002257054,0.000357856,0.0007611484],"category_scores_gemma":[0.0002097901,0.0001018269,0.0002435294,0.00012761,0.0001443595,0.0002633864,0.0002116667,0.0005052708,0.0001765031],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002442254,"about_ca_system_score_gemma":0.0001663846,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002943136,"about_ca_topic_score_gemma":0.0004387387,"domain_scores_codex":[0.9998633,0.00002707216,0.000009841809,0.00002146713,0.00004100018,0.00003730405],"domain_scores_gemma":[0.9999059,0.00002275618,0.000030059,0.000006104259,0.00002066766,0.00001451382],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001387877,0.0001145854,0.0001512805,0.00006955052,0.000009974309,0.00002381569,0.00001233092,0.0003122187,0.9972091,0.0000409242,0.00003324583,0.001884194],"study_design_scores_gemma":[0.00006636998,0.003228524,0.001044333,0.00001498658,0.00004210228,0.0001350175,0.00001789982,0.001085949,0.9928346,0.00002986442,0.001495379,0.00000486876],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99677,0.0008877633,0.001648337,0.00003896169,0.0000176215,0.000049277,0.00008342012,0.00002722448,0.0004774078],"genre_scores_gemma":[0.9945469,0.0008395207,0.003585935,0.00004848952,0.00001787955,0.00005169146,0.0002242738,0.00001305241,0.0006722445],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007611484,"threshold_uncertainty_score":0.00254631,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01212590569475026,"score_gpt":0.2801437626423497,"score_spread":0.2680178569475995,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}