{"id":"W4417113027","doi":"10.1038/s42255-025-01413-8","title":"Inhibition of IRAK4 by microbial trimethylamine blunts metabolic inflammation and ameliorates glycemic control","year":2025,"lang":"en","type":"article","venue":"Nature Metabolism","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill Genome Centre; University of Ottawa","funders":"NIHR Imperial Biomedical Research Centre; European Regional Development Fund; Instituto de Salud Carlos III; Medical Research Council; Canadian Institutes of Health Research; Agència de Gestió d'Ajuts Universitaris i de Recerca; Walloon excellence in life sciences and biotechnology; Centre hospitalier régional universitaire de Lille; Conseil Régional Hauts-de-France; Canada First Research Excellence Fund; Région Hauts-de-France; Fonds De La Recherche Scientifique - FNRS; Murdoch University; Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement; Institut National de la Santé et de la Recherche Médicale; University of Oxford; British Heart Foundation; National Institute for Health and Care Research; Universitat de Girona; Government of Canada; Rosetrees Trust; Institut Mérieux; Fondation Brain Canada; European Commission; Università degli Studi di Roma Tor Vergata; European Genomic Institute for Diabetes; Ontario Genomics; Université de Lille; CHIST-ERA; Australian Government; Université Catholique de Louvain; Agence Nationale de la Recherche; Institució Catalana de Recerca i Estudis Avançats; Trent University; Wellcome Trust; Centre National de la Recherche Scientifique; Nottingham Trent University; Genome Canada; University of Ottawa; Imperial College London; Heart and Stroke Foundation of Canada; McGill University","keywords":"Inflammation; Immune system; Kinome; TLR4; Glycemic; Microbiome; Insulin resistance; Glucokinase; Diabetes mellitus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001168303,0.0002739203,0.0003178983,0.0001422326,0.00009997083,0.0002086092,0.0002298025,0.0002330401,0.001888771],"category_scores_gemma":[0.000107804,0.00009330043,0.0002405298,0.00008099382,0.0001958108,0.0002081802,0.0001665732,0.0007279859,0.0002858963],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001512079,"about_ca_system_score_gemma":0.0002199668,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002788975,"about_ca_topic_score_gemma":0.0005310703,"domain_scores_codex":[0.9999337,0.00001274186,0.000007108339,0.0000126448,0.00001059874,0.0000231771],"domain_scores_gemma":[0.9999326,0.000007661803,0.00002371402,0.000008341131,0.000006525921,0.0000210806],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002267408,0.0001935874,0.0002135392,0.00008244408,0.00002384458,0.00003320468,0.000009747114,0.0001245144,0.9899369,0.000112469,0.0001195024,0.006882745],"study_design_scores_gemma":[0.0002636135,0.004391548,0.004298012,0.00001402023,0.0000541509,0.0001802165,0.00003968889,0.001136999,0.9862466,0.0001295757,0.003235625,0.00000995423],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936386,0.002258547,0.00218974,0.0002844161,0.0001144341,0.00002538386,0.0002114224,0.0001547378,0.001122837],"genre_scores_gemma":[0.9952934,0.00121787,0.001515069,0.0001267981,0.00002520057,0.00002609937,0.0001633426,0.0000180423,0.001614151],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001888771,"threshold_uncertainty_score":0.006318629,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002113461359812238,"score_gpt":0.2376126499637452,"score_spread":0.235499188603933,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}