{"id":"W4417113027","doi":"10.1038/s42255-025-01413-8","title":"Inhibition of IRAK4 by microbial trimethylamine blunts metabolic inflammation and ameliorates glycemic control","year":2025,"lang":"en","type":"article","venue":"Nature Metabolism","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill Genome Centre; University of Ottawa","funders":"NIHR Imperial Biomedical Research Centre; European Regional Development Fund; Instituto de Salud Carlos III; Medical Research Council; Canadian Institutes of Health Research; Agència de Gestió d'Ajuts Universitaris i de Recerca; Walloon excellence in life sciences and biotechnology; Centre hospitalier régional universitaire de Lille; Conseil Régional Hauts-de-France; Canada First Research Excellence Fund; Région Hauts-de-France; Fonds De La Recherche Scientifique - FNRS; Murdoch University; Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement; Institut National de la Santé et de la Recherche Médicale; University of Oxford; British Heart Foundation; National Institute for Health and Care Research; Universitat de Girona; Government of Canada; Rosetrees Trust; Institut Mérieux; Fondation Brain Canada; European Commission; Università degli Studi di Roma Tor Vergata; European Genomic Institute for Diabetes; Ontario Genomics; Université de Lille; CHIST-ERA; Australian Government; Université Catholique de Louvain; Agence Nationale de la Recherche; Institució Catalana de Recerca i Estudis Avançats; Trent University; Wellcome Trust; Centre National de la Recherche Scientifique; Nottingham Trent University; Genome Canada; University of Ottawa; Imperial College London; Heart and Stroke Foundation of Canada; McGill University","keywords":"Inflammation; Immune system; Kinome; TLR4; Glycemic; Microbiome; Insulin resistance; Glucokinase; Diabetes mellitus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002217866,0.000183716,0.0003459956,0.0001465635,0.00006648502,0.00002020255,0.00009383143,0.0005262116,0.00000691851],"category_scores_gemma":[0.0001149168,0.0001689407,0.00007703598,0.000232098,0.00008927817,0.000008773303,0.00005194264,0.0002783959,0.000002151419],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006517195,"about_ca_system_score_gemma":0.00009946693,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003341058,"about_ca_topic_score_gemma":0.00001510359,"domain_scores_codex":[0.998965,0.0001042308,0.0003264774,0.0003116583,0.00008386513,0.0002087236],"domain_scores_gemma":[0.9993763,0.00001767437,0.0001620681,0.000215862,0.0001778518,0.00005021939],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003505862,0.00003314228,0.0001517771,0.00005302026,0.00007275991,2.903109e-7,0.00003121511,0.00000228915,0.9904946,0.000787275,0.00482285,0.003200209],"study_design_scores_gemma":[0.002908909,0.00004798465,0.005925152,0.00002114587,0.0001112457,0.000003365969,0.00001549065,0.000007731625,0.8669317,0.0001614165,0.1237361,0.0001297284],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9463398,0.05172072,0.0004383458,0.0004726024,0.0002788095,0.000319282,0.0001746071,0.00001184292,0.0002439338],"genre_scores_gemma":[0.9960812,0.00176874,0.00038011,0.0006989869,0.00023082,0.00001145602,0.0003512311,0.00001412905,0.0004633214],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1235629,"threshold_uncertainty_score":0.6889202,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002113461359812238,"score_gpt":0.2376126499637452,"score_spread":0.235499188603933,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}