{"id":"W4417114893","doi":"10.7759/cureus.98694","title":"Early Versus Delayed Norepinephrine Initiation in Septic Shock: A Systematic Review and Meta-Analysis of Randomized and Observational Studies","year":2025,"lang":"en","type":"article","venue":"Cureus","topic":"Sepsis Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Heritage Medical Research Clinic","funders":"","keywords":"Observational study; Norepinephrine; Septic shock; Randomized controlled trial; Shock (circulatory); Hemodynamics; Meta-analysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01429316,0.002161016,0.0176021,0.004075069,0.0004884918,0.002827964,0.001650444,0.001704406,0.002482071],"category_scores_gemma":[0.03494543,0.001190531,0.03203956,0.005713872,0.0006260772,0.001454978,0.001243862,0.001970531,0.0002199559],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002181252,"about_ca_system_score_gemma":0.003212457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004847015,"about_ca_topic_score_gemma":0.009915748,"domain_scores_codex":[0.9897799,0.00506846,0.003101457,0.0009328412,0.0008439896,0.0002732278],"domain_scores_gemma":[0.9747385,0.01985573,0.003351565,0.0005902878,0.001234257,0.0002296003],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.004007386,0.00004096562,0.004473341,0.3789183,0.5950252,0.0001013657,0.00006326118,0.0005716935,0.0002066487,0.0001439758,0.000575705,0.01587219],"study_design_scores_gemma":[0.0009686606,0.0002652692,0.003746854,0.02462764,0.968538,0.00006822279,0.00003254797,0.0001643579,0.0001098225,0.0001991076,0.001258847,0.00002067506],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.004496722,0.9941982,0.0003877743,0.0001511516,0.000106621,0.0001760453,0.0003282717,0.00001417494,0.0001411308],"genre_scores_gemma":[0.1500818,0.8448418,0.002246244,0.0007817324,0.0002307074,0.0008478058,0.0007451156,0.00002596132,0.0001988792],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.0176021,"threshold_uncertainty_score":0.07559031,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2973357925840767,"score_gpt":0.4357070575450778,"score_spread":0.1383712649610011,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}