{"id":"W4417116661","doi":"10.64898/2025.12.01.691211","title":"Organoid Pharmacotyping of Pancreatic Cancer Enables Functional Precision Oncology and Drug Repurposing","year":2025,"lang":"","type":"article","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Cameco (Canada); Saskatchewan Cancer Agency; University of Saskatchewan","funders":"","keywords":"Pancreatic cancer; Organoid; Precision medicine; Drug discovery; Drug; Drug repositioning; Drug development; Synthetic lethality; KRAS","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005080868,0.0004796108,0.0005947021,0.0006688336,0.0002638024,0.001071028,0.000323043,0.0003621712,0.001541721],"category_scores_gemma":[0.0005034035,0.0002185186,0.0004747307,0.0006057647,0.0003833652,0.0003385115,0.0007309219,0.0006485469,0.0005895708],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005588458,"about_ca_system_score_gemma":0.0005518845,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008836199,"about_ca_topic_score_gemma":0.00126074,"domain_scores_codex":[0.9995552,0.000073412,0.00003941512,0.0001366674,0.0001502986,0.00004502624],"domain_scores_gemma":[0.9996116,0.00007271114,0.00009222738,0.0001047484,0.00006755637,0.00005116472],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004509043,0.00006899717,0.01229471,0.0002259876,0.00004750666,0.0002123933,0.00005894611,0.003612963,0.9620344,0.0004254832,0.000387491,0.02018026],"study_design_scores_gemma":[0.00003769117,0.0009919603,0.03766958,0.00004319177,0.0001457222,0.001483353,0.0002394987,0.007566228,0.9336962,0.0009658212,0.01711516,0.00004560785],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9456822,0.00304651,0.03596393,0.0002813298,0.00003124834,0.0002762991,0.01018054,0.0007238854,0.003814169],"genre_scores_gemma":[0.9691497,0.001770938,0.01874452,0.0001757434,0.000009629561,0.0001956444,0.008261479,0.000109466,0.001582954],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001541721,"threshold_uncertainty_score":0.00515759,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02098294224754977,"score_gpt":0.3060633156324452,"score_spread":0.2850803733848954,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}