{"id":"W4417118034","doi":"10.1042/ebc20253020","title":"Epigenetic changes and their potential reversibility in mental health disorders","year":2025,"lang":"en","type":"article","venue":"Essays in Biochemistry","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"","keywords":"Epigenetics; Histone; DNA methylation; Epigenesis; Disease; Psychological intervention","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003802806,0.0001849115,0.000235741,0.000278185,0.0004061293,0.0008697399,0.0002602157,0.0009298756,0.002651571],"category_scores_gemma":[0.0005706855,0.00009768978,0.0001845013,0.0002050202,0.001818673,0.0008046125,0.0007386608,0.001058156,0.0003795794],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000454729,"about_ca_system_score_gemma":0.0003918118,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005041735,"about_ca_topic_score_gemma":0.001077416,"domain_scores_codex":[0.9998498,0.00005474263,0.00000759381,0.00002797565,0.00003331117,0.00002656842],"domain_scores_gemma":[0.9998478,0.00007396372,0.00002324098,0.00001357583,0.00001785823,0.00002352637],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0002728103,0.0001228882,0.004343041,0.001753859,0.0001577088,0.002295903,0.004761593,0.001113655,0.1026256,0.3068955,0.02670941,0.548948],"study_design_scores_gemma":[0.00003897258,0.0002974023,0.01944679,0.0006877317,0.00008759761,0.002559702,0.002708479,0.0005065076,0.0285442,0.2282389,0.7168196,0.00006403964],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.05335632,0.8376957,0.005955881,0.05595796,0.003436855,0.00002212683,0.0001382061,0.0001034755,0.04333346],"genre_scores_gemma":[0.4667758,0.4916882,0.003818223,0.006568545,0.002814215,0.00003971564,0.00008219577,0.00002540347,0.02818771],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002651571,"threshold_uncertainty_score":0.008870363,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004081202345365397,"score_gpt":0.2516183719523948,"score_spread":0.2475371696070294,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}