{"id":"W4417120229","doi":"10.64898/2025.12.04.25340995","title":"Development and Validation of Minimal Disease Activity, Disease Flare, and Minimal Clinically Important Difference for Children with Chronic Nonbacterial Osteomyelitis Using a Consensus and Data-Driven Approach","year":2025,"lang":"","type":"article","venue":"medRxiv","topic":"Osteomyelitis and Bone Disorders Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Stollery Children's Hospital","funders":"","keywords":"Minimal clinically important difference; Disease; Clinical trial; Observational study; Cohort; MEDLINE; Cohort study","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009727755,0.0005214016,0.001025528,0.0002547256,0.0003391379,0.0001843346,0.0002712636,0.0001471503,0.00001809675],"category_scores_gemma":[0.0008447373,0.0004417061,0.00007448331,0.0002640094,0.001122172,0.0001736887,0.0009113592,0.000299529,2.561012e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008584725,"about_ca_system_score_gemma":0.003338108,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009725665,"about_ca_topic_score_gemma":0.00006512924,"domain_scores_codex":[0.9957532,0.0002466776,0.001233985,0.001501156,0.0005723554,0.0006925681],"domain_scores_gemma":[0.9971569,0.0004362954,0.0004973672,0.0007995009,0.0002758084,0.0008340987],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01550435,0.0005016312,0.9208056,0.003726233,0.0006029573,0.00006232104,0.0003193982,0.000002568711,0.008694162,0.00004964505,0.000009580574,0.04972152],"study_design_scores_gemma":[0.01038792,0.001145488,0.9654288,0.001385557,0.001353049,0.0000332482,0.0001877677,0.01869914,0.0007828149,0.00002131139,0.0001159973,0.000458957],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896248,0.00367022,0.0006135118,0.0006988151,0.000101993,0.003184118,0.002077181,0.00001699394,0.0000123845],"genre_scores_gemma":[0.9918624,0.000869122,0.005966834,0.00002513298,0.0002549753,0.000101978,0.0007925449,0.00004622834,0.0000807617],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04926256,"threshold_uncertainty_score":0.9998035,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05391474961096829,"score_gpt":0.3384659072472825,"score_spread":0.2845511576363142,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}