{"id":"W4417120229","doi":"10.64898/2025.12.04.25340995","title":"Development and Validation of Minimal Disease Activity, Disease Flare, and Minimal Clinically Important Difference for Children with Chronic Nonbacterial Osteomyelitis Using a Consensus and Data-Driven Approach","year":2025,"lang":"","type":"article","venue":"medRxiv","topic":"Osteomyelitis and Bone Disorders Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Stollery Children's Hospital","funders":"","keywords":"Minimal clinically important difference; Disease; Clinical trial; Observational study; Cohort; MEDLINE; Cohort study","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.1542816,0.0006809998,0.001498917,0.00475724,0.00133149,0.003532706,0.003724847,0.001545741,0.001729521],"category_scores_gemma":[0.2272096,0.0004794041,0.002321771,0.002103656,0.001331727,0.002343152,0.004790804,0.002844444,0.0006339309],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004364462,"about_ca_system_score_gemma":0.01092967,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004388964,"about_ca_topic_score_gemma":0.006942431,"domain_scores_codex":[0.8761093,0.07742289,0.01786442,0.005595656,0.02158139,0.001426337],"domain_scores_gemma":[0.7503091,0.1056832,0.03167128,0.0151791,0.09229825,0.004859082],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002222738,0.001221988,0.52685,0.005831124,0.001439502,0.0003583032,0.01120064,0.01006421,0.004142488,0.008638314,0.01817621,0.4098545],"study_design_scores_gemma":[0.002476934,0.006504573,0.6453952,0.01254316,0.002358227,0.0017121,0.02709315,0.1527362,0.02796579,0.03434896,0.08610275,0.0007628122],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.4550646,0.003770012,0.4607511,0.007930672,0.0006872595,0.03766516,0.009978871,0.001329043,0.02282338],"genre_scores_gemma":[0.5304528,0.0004194008,0.450996,0.0009922981,0.00009649568,0.01171074,0.004691857,0.00007420337,0.0005662286],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.1542816,"threshold_uncertainty_score":0.815929,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05391474961096829,"score_gpt":0.3384659072472825,"score_spread":0.2845511576363142,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}