{"id":"W4417120303","doi":"10.12688/f1000research.172881.1","title":"Methods2AOP: A Collaboration to Strengthen the Integration of Test Methods into the Adverse Outcome Pathway Framework","year":2025,"lang":"en","type":"article","venue":"F1000Research","topic":"Health Systems, Economic Evaluations, Quality of Life","field":"Economics, Econometrics and Finance","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Environment and Climate Change Canada","funders":"","keywords":"Adverse Outcome Pathway; Test (biology); CLARITY; Transparency (behavior); Key (lock); Outcome (game theory); Work (physics); Visibility; Conceptual framework","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.05847212,0.0001734226,0.0006608627,0.0005321606,0.0004540753,0.0001297046,0.0009267495,0.0001817794,0.0003649032],"category_scores_gemma":[0.07868215,0.0001320182,0.0001304334,0.001731414,0.0001933238,0.0002601295,0.0002393217,0.0005072528,0.0005111817],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005371176,"about_ca_system_score_gemma":0.0004384956,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001926027,"about_ca_topic_score_gemma":0.0007407963,"domain_scores_codex":[0.9933118,0.002574679,0.003040099,0.0004786752,0.0002151928,0.0003795954],"domain_scores_gemma":[0.9765828,0.02070964,0.000896024,0.001265846,0.0004188702,0.0001268476],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000582,0.0001593367,0.03982121,0.0002688153,0.0001263712,4.121187e-7,0.03279192,0.000748851,0.0003940094,0.8802175,0.0239833,0.02143008],"study_design_scores_gemma":[0.000942904,0.0004015261,0.1387358,0.0003979653,0.00003236563,0.000001180232,0.04627356,0.04518247,0.00236332,0.3500567,0.4150116,0.000600607],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.0803922,0.002049766,0.5499177,0.351584,0.00134009,0.004045398,0.0003177829,0.00008621471,0.01026681],"genre_scores_gemma":[0.5792983,0.0001617451,0.3910555,0.01809949,0.0004797349,0.001403928,0.00004140173,0.00006535858,0.009394594],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.5301608,"threshold_uncertainty_score":0.9695011,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.5152115860417836,"score_gpt":0.5920295398131756,"score_spread":0.076817953771392,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}