{"id":"W4417129956","doi":"10.58931/cht.2025.4378","title":"Practical Management of Aggressive B-Cell Lymphomas with CD20×CD3 Bispecific Antibodies","year":2025,"lang":"","type":"article","venue":"Canadian Hematology Today","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval","funders":"Centre Hospitalier Universitaire de Québec; Royal College of Physicians and Surgeons of Canada; Université Laval","keywords":"Chimeric antigen receptor; Lymphoma; Cytokine release syndrome; Bispecific antibody; Blinatumomab; Immunotherapy; Aggressive lymphoma; Antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006274491,0.0005405461,0.0006541811,0.0008480456,0.001027281,0.001032234,0.0007992313,0.001135064,0.002452562],"category_scores_gemma":[0.001185868,0.0001904851,0.0003828459,0.0006049423,0.0006466706,0.0007305716,0.0008537206,0.00253805,0.001007995],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002225754,"about_ca_system_score_gemma":0.003716894,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02280752,"about_ca_topic_score_gemma":0.05708534,"domain_scores_codex":[0.9996483,0.00006740518,0.00003554856,0.00002511686,0.000146862,0.00007683713],"domain_scores_gemma":[0.9996805,0.00005569283,0.00004761062,0.00001208244,0.0001059355,0.00009815899],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001935454,0.0001348266,0.005011838,0.001540389,0.00005810179,0.02801672,0.0005499453,0.001372153,0.009086231,0.006155546,0.1440448,0.803836],"study_design_scores_gemma":[0.0001616378,0.0003032489,0.009619334,0.001660837,0.0001337433,0.07048607,0.001050824,0.001279347,0.00537959,0.009809367,0.9000502,0.0000657612],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.03862166,0.666639,0.06616753,0.103793,0.00348578,0.0006987299,0.0004028018,0.001510859,0.1186807],"genre_scores_gemma":[0.2750604,0.5487254,0.09837367,0.04293943,0.007090997,0.0005581055,0.001010074,0.0002420088,0.02599985],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.02280752,"threshold_uncertainty_score":0.04534948,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02374694346707146,"score_gpt":0.3227101856237286,"score_spread":0.2989632421566571,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}