{"id":"W4417136205","doi":"10.2196/83872","title":"Immunogenicity of Adalimumab in Bacterial Molecular Mimicry: In Silico Analysis","year":2025,"lang":"en","type":"article","venue":"JMIR Bioinformatics and Biotechnology","topic":"vaccines and immunoinformatics approaches","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Immunogenicity; In silico; Epitope; Adalimumab; Antibody; Molecular mimicry; Monoclonal antibody","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005493365,0.0008232135,0.0008335027,0.0005088164,0.0003879048,0.0006626977,0.0005000308,0.0007115283,0.002080638],"category_scores_gemma":[0.0008742044,0.0002888443,0.001130859,0.000398599,0.0001592672,0.0003174138,0.0002619482,0.0004380692,0.000650761],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006932291,"about_ca_system_score_gemma":0.0007114395,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002368586,"about_ca_topic_score_gemma":0.002342864,"domain_scores_codex":[0.9997504,0.00007906593,0.00001466802,0.00005354585,0.00006046283,0.00004185982],"domain_scores_gemma":[0.9996038,0.0002661398,0.00004992594,0.00001700074,0.00003983751,0.00002333648],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.001346168,0.0009665209,0.03609629,0.0009709063,0.0004997712,0.001313603,0.0001128804,0.8263344,0.1102879,0.002343923,0.001575754,0.01815203],"study_design_scores_gemma":[0.00007013915,0.0003621407,0.004223371,0.00001859725,0.0001574241,0.0002292371,0.0000352353,0.97974,0.01332303,0.000567021,0.001259819,0.00001412039],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9838617,0.0005320511,0.01140574,0.0001391725,0.00002154556,0.00006415616,0.001078774,0.0004061846,0.002490515],"genre_scores_gemma":[0.9802573,0.0004558747,0.01591934,0.00007548217,0.000009260831,0.00008212584,0.002470098,0.00006610662,0.0006643212],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002368586,"threshold_uncertainty_score":0.006960452,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004132130783972321,"score_gpt":0.2305700932021023,"score_spread":0.22643796241813,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}