{"id":"W4417144082","doi":"10.1186/s43556-025-00361-9","title":"Gastrointestinal cancer: molecular pathogenesis and targeted therapy","year":2025,"lang":"en","type":"article","venue":"Molecular Biomedicine","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Natural Science Foundation of China","keywords":"Targeted therapy; Epigenetics; Immunotherapy; Tumor microenvironment; Cancer; Immune system; Histone; Immune checkpoint; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002004746,0.0002514375,0.0003787442,0.0003266956,0.00007015382,0.00001696278,0.0001003399,0.00006254533,0.0001633521],"category_scores_gemma":[0.00004232781,0.0002001094,0.0001233233,0.0007408101,0.0003667453,0.00002259556,0.00004118121,0.0001357144,0.000002778896],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008164317,"about_ca_system_score_gemma":0.0002026183,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002568929,"about_ca_topic_score_gemma":0.000004505511,"domain_scores_codex":[0.9986367,0.00004946119,0.0003059286,0.000405477,0.0002763939,0.0003260628],"domain_scores_gemma":[0.9992881,0.00002257353,0.00006878871,0.0003569744,0.0001191393,0.0001444557],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0010718,0.00009315538,0.009552228,0.00008395468,0.0002312915,0.0005355477,0.0000300995,7.2354e-7,0.9132146,0.0001110272,0.0009951275,0.07408049],"study_design_scores_gemma":[0.01745433,0.002142135,0.1315745,0.001794577,0.0004345539,0.0009553651,0.0002036738,0.0003285145,0.7896366,0.0003196651,0.05461432,0.0005418261],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9227449,0.05260247,0.009513384,0.01329138,0.0002099368,0.0005950404,0.00001899257,0.0001098005,0.0009141198],"genre_scores_gemma":[0.984126,0.002340286,0.0023612,0.01031497,0.00006575573,0.00008093224,0.00005895561,0.00003579287,0.0006160614],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.123578,"threshold_uncertainty_score":0.8160226,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0075742001838341,"score_gpt":0.2754242888073307,"score_spread":0.2678500886234966,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}