{"id":"W4417151226","doi":"10.1016/j.jagp.2026.05.008","title":"The Impact of Anticholinergic Burden on the Development of Mild Behavioral Impairment","year":2025,"lang":"en","type":"preprint","venue":"American Journal of Geriatric Psychiatry","topic":"Pharmaceutical Practices and Patient Outcomes","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute on Aging; National Institutes of Health","keywords":"Anticholinergic; Risk assessment; Activities of daily living; MEDLINE; Anticholinergic agents","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001185665,0.0003311741,0.0002337524,0.0005473857,0.0003308071,0.0007047642,0.0003572752,0.0004120309,0.002157309],"category_scores_gemma":[0.008180811,0.0001903402,0.0006390918,0.0005411405,0.0001934532,0.0004730956,0.0007693084,0.0006078595,0.0002233891],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002966891,"about_ca_system_score_gemma":0.0003510959,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006649697,"about_ca_topic_score_gemma":0.008969037,"domain_scores_codex":[0.9993109,0.0002425269,0.00006685078,0.0001106392,0.0001481722,0.0001210016],"domain_scores_gemma":[0.9944681,0.0009910576,0.003126995,0.0002919964,0.0004771937,0.0006447345],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001582455,0.00002472763,0.9967758,0.00001103849,0.00006740212,0.00003755643,0.00001911259,0.00006124288,0.00009030366,0.00001012875,0.00005197576,0.002692434],"study_design_scores_gemma":[0.000001076438,0.0000401552,0.999759,0.000004197897,0.00001209618,0.00004970981,0.00001401397,0.00006621237,0.00001502343,0.000007928971,0.00002957565,9.004658e-7],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976287,0.0008391058,0.00009751024,0.0001300974,0.000009775861,0.000006772871,0.0004381414,0.000006362772,0.0008435375],"genre_scores_gemma":[0.9993697,0.0001666475,0.00007398972,0.00001337652,0.00001476552,0.000003191483,0.0002207661,0.000001241395,0.0001363529],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006649697,"threshold_uncertainty_score":0.01322198,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06580331548914066,"score_gpt":0.4297937425177689,"score_spread":0.3639904270286282,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}