{"id":"W4417152949","doi":"10.1056/nejmoa2509807","title":"Prime Editing for p47 <sup>phox</sup> -Deficient Chronic Granulomatous Disease","year":2025,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia; Centre Hospitalier Universitaire Sainte-Justine","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute","keywords":"Chronic granulomatous disease; NADPH oxidase; Myeloid cells; Exon; Myeloid; Genome editing; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004605681,0.0002576338,0.000236812,0.0001177102,0.000181471,0.000367635,0.0002450134,0.0004754426,0.003087375],"category_scores_gemma":[0.000274086,0.00009506762,0.00025878,0.00006505875,0.0003142962,0.0002015104,0.0002451709,0.0005819413,0.0004475291],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000213923,"about_ca_system_score_gemma":0.0002071976,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002521293,"about_ca_topic_score_gemma":0.000457622,"domain_scores_codex":[0.999859,0.00004006385,0.0000107643,0.00003236156,0.00003223909,0.00002564989],"domain_scores_gemma":[0.9998723,0.00003165695,0.00003667112,0.00002005891,0.000008624127,0.00003066209],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001963429,0.000619825,0.002602678,0.0002304989,0.00004436134,0.001455482,0.0001226063,0.0003295513,0.9449199,0.001759142,0.002636344,0.04331606],"study_design_scores_gemma":[0.001764077,0.01578745,0.01443174,0.0001228285,0.0002623433,0.01824533,0.0001571987,0.004264132,0.8551044,0.001245851,0.08857424,0.00004034668],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9750495,0.003092744,0.01348547,0.0009541432,0.0003075483,0.0007688639,0.001249029,0.0003759707,0.004716679],"genre_scores_gemma":[0.9861735,0.0009782633,0.008782428,0.000457803,0.00005007726,0.0002858397,0.0008898545,0.00004608518,0.002336072],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003087375,"threshold_uncertainty_score":0.01032829,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01181061350964207,"score_gpt":0.2609317163400489,"score_spread":0.2491211028304068,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}