{"id":"W4417156840","doi":"10.1056/nejmoa2514663","title":"Teclistamab plus Daratumumab in Relapsed or Refractory Multiple Myeloma","year":2025,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Institute of Cancer Research; University of Calgary","funders":"Johnson and Johnson","keywords":"Daratumumab; Multiple myeloma; Refractory (planetary science); Progression-free survival; Overall survival; Chemoimmunotherapy; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009157004,0.0002180916,0.0008311381,0.0008301496,0.00006595996,0.00001147355,0.0001870827,0.0001252549,0.0004232903],"category_scores_gemma":[0.003782571,0.0001238241,0.00009710435,0.0006066831,0.0001378985,0.00008958881,0.00004067635,0.000825081,0.00001164314],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004236089,"about_ca_system_score_gemma":0.001181446,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003825602,"about_ca_topic_score_gemma":0.0006237093,"domain_scores_codex":[0.9977129,0.0001537968,0.0008382057,0.0002091081,0.0007083199,0.0003777068],"domain_scores_gemma":[0.9979612,0.0007603527,0.0002444446,0.0003098684,0.0002584124,0.0004657033],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.06067694,0.0007718392,0.1238439,0.0003226124,0.0006536106,0.0156611,0.001571921,0.00003392807,0.008360716,0.0001621549,0.0372269,0.7507144],"study_design_scores_gemma":[0.4984676,0.006790399,0.2752916,0.004019465,0.0003050105,0.001992402,0.0007080568,0.0007526717,0.001251812,0.000407868,0.2098164,0.000196749],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9657171,0.005583017,0.0004441112,0.01490173,0.0009584811,0.0005721845,0.000005508254,0.00003002748,0.01178784],"genre_scores_gemma":[0.9882622,0.0006718552,0.00101328,0.0005037177,0.001195375,0.000004600977,0.00001317048,0.00001902272,0.00831678],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7505177,"threshold_uncertainty_score":0.50494,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03293884961373357,"score_gpt":0.3410807698555924,"score_spread":0.3081419202418588,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}