{"id":"W4417160052","doi":"10.1002/acn3.70272","title":"Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease","year":2025,"lang":"en","type":"article","venue":"Annals of Clinical and Translational Neurology","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Domtar (Canada)","funders":"National Institutes of Health","keywords":"Disease; Proteomics; MEDLINE; Disease monitoring; Proteome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007539454,0.0002773807,0.000266788,0.0005518657,0.0001936309,0.0004117749,0.0001506076,0.0002357358,0.0004659014],"category_scores_gemma":[0.0007527296,0.0001245621,0.0001953882,0.0003294164,0.0001999948,0.000157766,0.0003063365,0.0001542096,0.0001196566],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002203665,"about_ca_system_score_gemma":0.0002049063,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005090211,"about_ca_topic_score_gemma":0.0009999741,"domain_scores_codex":[0.9997719,0.00004231362,0.00001805906,0.00008127737,0.00006303978,0.00002330989],"domain_scores_gemma":[0.9996843,0.00005415899,0.0001416233,0.00002107814,0.00006186283,0.0000370354],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001660523,0.0002104668,0.4498788,0.0002094086,0.0004585115,0.0004651283,0.0002825163,0.0003198006,0.5286202,0.000147537,0.000299393,0.01744769],"study_design_scores_gemma":[0.00004659183,0.0009727913,0.932312,0.00001911385,0.0002409724,0.001037131,0.0001278992,0.0007552824,0.06356625,0.00009015884,0.0008238835,0.000007940249],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985448,0.0006202668,0.0004586593,0.00001543007,0.000002738355,0.000013698,0.0001800001,0.000008119948,0.0001562997],"genre_scores_gemma":[0.9983897,0.0002017552,0.0009064188,0.00004250145,0.000004729419,0.00001877588,0.0002628733,0.000002729917,0.0001704822],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007539454,"threshold_uncertainty_score":0.003987253,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1428869882676866,"score_gpt":0.4238038237068736,"score_spread":0.280916835439187,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}