{"id":"W4417162435","doi":"10.1038/s44319-025-00620-4","title":"An Argonaute protein traffics from nematode to mouse and is a vaccine against parasitic nematodes","year":2025,"lang":"en","type":"article","venue":"EMBO Reports","topic":"Parasites and Host Interactions","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"University of Edinburgh; Rural and Environment Science and Analytical Services Division; Darwin Trust of Edinburgh; National Institutes of Health; Consejo Nacional de Ciencia y Tecnología; Wellcome Trust","keywords":"Argonaute; Context (archaeology); Internalization; Nematode; Function (biology); Gene; Recombinant DNA; Extracellular","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001135428,0.0001881956,0.0003269404,0.0001341399,0.0002041336,0.00005340387,0.00009254691,0.0001688093,0.0002518257],"category_scores_gemma":[0.00005517457,0.0001737047,0.0000648736,0.0001341084,0.00003071886,0.0001264079,0.00003739456,0.0002062471,0.0001171999],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002531485,"about_ca_system_score_gemma":0.0000568818,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003475462,"about_ca_topic_score_gemma":0.0002037137,"domain_scores_codex":[0.9987659,0.00006479133,0.0004201,0.0004506748,0.00002957913,0.0002689236],"domain_scores_gemma":[0.9991963,0.00005304693,0.0001258278,0.0005069055,0.00006207359,0.00005588022],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001131529,0.0003421305,0.01229948,0.00002754389,0.0003019971,0.0002502025,0.001082463,0.00006039331,0.9691984,0.0005863227,0.01296344,0.00277445],"study_design_scores_gemma":[0.001143101,0.0002815284,0.09132142,0.0004012656,0.0001928947,0.0006877179,0.0007186232,0.0001191601,0.8019703,0.001832598,0.1006325,0.0006988182],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951983,0.0009065908,0.0004078053,0.0009897241,0.0003523068,0.0004446997,0.00004115084,0.0001372884,0.001522138],"genre_scores_gemma":[0.9915097,0.00002293956,0.0002711918,0.001391505,0.00002472991,0.00008539026,0.0001611009,0.00001562515,0.006517766],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1672281,"threshold_uncertainty_score":0.7083474,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007375472076504428,"score_gpt":0.2919824536509634,"score_spread":0.284606981574459,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}