{"id":"W4417174819","doi":"10.1093/braincomms/fcaf478","title":"Accelerated forgetting in presymptomatic Alzheimer’s: mediation by prefrontal cortical degeneration","year":2025,"lang":"en","type":"article","venue":"Brain Communications","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nickel Institute","funders":"University College London Hospitals Biomedical Research Centre; Economic and Social Research Council; Alzheimer’s Research UK; Wellcome Trust; Alzheimer’s Society; Rosetrees Trust; UK Dementia Research Institute; National Institute for Health and Care Research","keywords":"Forgetting; Temporal lobe; Prefrontal cortex; Degeneration (medical); Recall; Pathological; Association (psychology); Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000402837,0.0003960014,0.0001959671,0.0005094871,0.0001553912,0.0002408423,0.0002329781,0.0002731773,0.001154725],"category_scores_gemma":[0.001327133,0.0001485167,0.0001265015,0.0001371163,0.0004161159,0.0002326189,0.0002060064,0.0001841212,0.00006838249],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001718148,"about_ca_system_score_gemma":0.0001356951,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001416371,"about_ca_topic_score_gemma":0.001558966,"domain_scores_codex":[0.9999191,0.00001929434,0.000007786161,0.00001644777,0.00002179148,0.00001569029],"domain_scores_gemma":[0.9989586,0.0002196702,0.0005622712,0.00009271442,0.00008181785,0.00008482594],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003562788,0.0004376929,0.7686973,0.0001324007,0.0002348015,0.006177786,0.00105463,0.000673312,0.1956537,0.0004915848,0.0002069486,0.02267708],"study_design_scores_gemma":[0.00002220426,0.0004902614,0.9898747,0.000008294134,0.00003313629,0.002734316,0.0001327412,0.0006434857,0.005594557,0.0003844947,0.00007630964,0.000005440547],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996075,0.0000830509,0.0001471473,0.00001064777,0.000001053168,0.000002011016,0.00002107499,0.000004124661,0.0001233622],"genre_scores_gemma":[0.9997575,0.00003350157,0.00009911846,0.000003432995,0.000002363055,0.000001511891,0.00002261878,9.364063e-7,0.00007908987],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001416371,"threshold_uncertainty_score":0.003862917,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0501865303469142,"score_gpt":0.3918541868938251,"score_spread":0.3416676565469109,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}