{"id":"W4417180070","doi":"10.1002/mds.70142","title":"Longitudinal Dynamics of Plasma Neurofilament Light Chain in Hereditary Spastic Paraplegia Type 11 ( <scp>HSP</scp> ‐ <scp> <i>SPG11</i> </scp> ) and Type 15 ( <scp>HSP</scp> ‐ <scp> <i>ZFYVE26</i> </scp> )","year":2025,"lang":"en","type":"article","venue":"Movement Disorders","topic":"Hereditary Neurological Disorders","field":"Neuroscience","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"National Institute of Neurological Disorders and Stroke; Spastic Paraplegia Foundation","keywords":"Hereditary spastic paraplegia; Paraplegia; Degenerative disease; Spasticity; Central nervous system disease; Spastic; Neurological disorder","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003801078,0.0001862355,0.0002149597,0.0004565199,0.0002001449,0.0003355842,0.0001428457,0.0004164897,0.001014856],"category_scores_gemma":[0.00104491,0.0001285506,0.0001650283,0.0003470173,0.0001735301,0.0002600176,0.0002403927,0.0003212923,0.0002287251],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002540854,"about_ca_system_score_gemma":0.0001029267,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001219786,"about_ca_topic_score_gemma":0.001055694,"domain_scores_codex":[0.9998131,0.000029124,0.00001656623,0.00008073885,0.00003025784,0.00003022716],"domain_scores_gemma":[0.9991782,0.0001321302,0.0004105977,0.00003658334,0.0001005096,0.0001419574],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001431505,0.00006960393,0.9812921,0.00001928162,0.0001002046,0.0002959102,0.0001311502,0.0001533294,0.01074343,0.00002313106,0.000139352,0.00560113],"study_design_scores_gemma":[0.000006930267,0.0002699911,0.9981324,0.000002682807,0.00002775485,0.0004859671,0.00004741049,0.0001964998,0.000720451,0.00001530932,0.0000914126,0.000003317121],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994285,0.0001566163,0.0001000914,0.000009248513,0.0000016753,0.00000251192,0.0001795002,0.000005516901,0.000116297],"genre_scores_gemma":[0.9994185,0.0000461231,0.0000923886,0.000010014,0.000003136481,0.000005897639,0.0002805834,0.000001303406,0.0001420281],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001219786,"threshold_uncertainty_score":0.003395021,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01475377190269458,"score_gpt":0.23592227331442,"score_spread":0.2211685014117254,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}