{"id":"W4417180070","doi":"10.1002/mds.70142","title":"Longitudinal Dynamics of Plasma Neurofilament Light Chain in Hereditary Spastic Paraplegia Type 11 ( <scp>HSP</scp> ‐ <scp> <i>SPG11</i> </scp> ) and Type 15 ( <scp>HSP</scp> ‐ <scp> <i>ZFYVE26</i> </scp> )","year":2025,"lang":"en","type":"article","venue":"Movement Disorders","topic":"Hereditary Neurological Disorders","field":"Neuroscience","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"National Institute of Neurological Disorders and Stroke; Spastic Paraplegia Foundation","keywords":"Hereditary spastic paraplegia; Paraplegia; Degenerative disease; Spasticity; Central nervous system disease; Spastic; Neurological disorder","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow"],"consensus_categories":["metaepi_narrow"],"category_scores_codex":[0.001071053,0.002030608,0.001997667,0.001317905,0.0006690423,0.0003476471,0.002314942,0.0008919595,0.00005442374],"category_scores_gemma":[0.01209388,0.002073511,0.0005478526,0.004304602,0.001286854,0.0009056419,0.001606263,0.001935793,0.0002150443],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004134191,"about_ca_system_score_gemma":0.0005110793,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007002599,"about_ca_topic_score_gemma":0.003211482,"domain_scores_codex":[0.9873903,0.001060359,0.002438913,0.00357154,0.00219112,0.003347711],"domain_scores_gemma":[0.9881715,0.0077385,0.0009898097,0.001906713,0.0003047163,0.0008888087],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001732598,0.008279307,0.4976439,0.002182057,0.0006211827,0.001833052,0.004096572,0.01742166,0.05202524,0.01505598,0.3978326,0.002835213],"study_design_scores_gemma":[0.02724614,0.01435225,0.3969292,0.001728062,0.001578264,0.0001286819,0.02599369,0.08256418,0.07055636,0.07204015,0.3052675,0.001615515],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9668315,0.001884748,0.0004509306,0.001834386,0.003989958,0.003013555,0.0003457594,0.0005595621,0.02108958],"genre_scores_gemma":[0.9761107,0.003281063,0.0002393545,0.01246574,0.0002521896,0.0003161006,0.0002568293,0.0003320798,0.006745967],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1007146,"threshold_uncertainty_score":0.9992436,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01475377190269458,"score_gpt":0.23592227331442,"score_spread":0.2211685014117254,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}