{"id":"W4417187569","doi":"10.1016/j.jcmgh.2025.101703","title":"The Use of Human Liver Chimeric Mice to Study Hepatitis C Virus Antibody Escape: Implications for Vaccine Development","year":2025,"lang":"en","type":"editorial","venue":"Cellular and Molecular Gastroenterology and Hepatology","topic":"Hepatitis C virus research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Canadian Institutes of Health Research; National Institutes of Health; Centre National de la Recherche Scientifique; Agence Nationale de la Recherche; Agence Nationale de Recherches sur le Sida et les Hépatites Virales; Natural Sciences and Engineering Research Council of Canada; European Commission; Institut National de la Santé et de la Recherche Médicale; Institut Universitaire de France; Université de Strasbourg; Styrelsen för Internationellt Utvecklingssamarbete","keywords":"Hepatitis C virus; Human liver; Antibody; Hepacivirus; Antibody response; Hepatitis C","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003917666,0.0003745615,0.0009855279,0.0003386747,0.0004488722,0.00003560656,0.0002543644,0.0004823286,0.000009633003],"category_scores_gemma":[0.000464519,0.0003183127,0.0001213835,0.0001390831,0.000214089,0.00002990561,0.0004221762,0.0005587173,0.000002307324],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005149435,"about_ca_system_score_gemma":0.0002628795,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006456206,"about_ca_topic_score_gemma":0.002995087,"domain_scores_codex":[0.9973546,0.0003874405,0.0006917932,0.0007450377,0.0002138679,0.000607305],"domain_scores_gemma":[0.9980661,0.0004771286,0.0001986813,0.0005626208,0.0004684138,0.0002271122],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002799787,0.001231254,0.6582398,0.0007815589,0.002827078,0.0003316172,0.0006306296,8.767693e-7,0.0760734,0.0002305178,0.245651,0.01120248],"study_design_scores_gemma":[0.006103867,0.008271654,0.1024722,0.0001561905,0.001463464,0.00005514363,0.00003385178,0.00008943344,0.006653633,0.00005688179,0.8742429,0.000400821],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9652012,0.001685571,0.009606599,0.0008954222,0.01927205,0.002980451,0.0003142364,0.00002885563,0.00001564091],"genre_scores_gemma":[0.9566811,0.01132114,0.005469167,0.001865729,0.01726235,0.002198305,0.004155941,0.0001937189,0.0008525025],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6285918,"threshold_uncertainty_score":0.9999269,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02392885649182225,"score_gpt":0.3321730804698807,"score_spread":0.3082442239780585,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}