{"id":"W4417192384","doi":"10.1038/s41598-026-58117-6","title":"Omics signature of new-onset mild cognitive impairment and dementia in a population- based study","year":2025,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Biomedical Research Council","keywords":"Dementia; Proteomics; Omics; Metabolomics; Neurocognitive; Disease; Cognitive impairment; Ageing; Cognitive decline","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001082442,0.0004541858,0.0004924458,0.0009206781,0.0003925687,0.001006181,0.0003204241,0.0005184393,0.001250501],"category_scores_gemma":[0.002208506,0.0001900986,0.0006928979,0.001172511,0.0002068242,0.0003444113,0.0007044654,0.0005025429,0.0002479985],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002668674,"about_ca_system_score_gemma":0.0003216616,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004414535,"about_ca_topic_score_gemma":0.004389537,"domain_scores_codex":[0.9995735,0.0001303751,0.00005199415,0.0001494043,0.00005585046,0.00003890867],"domain_scores_gemma":[0.9993165,0.0001077477,0.0002173087,0.0001310552,0.000118328,0.0001091247],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004063888,0.00005477194,0.9941935,0.00002340295,0.0004361292,0.0002146123,0.000120571,0.0001576087,0.001325035,0.00003884675,0.0002326657,0.002796585],"study_design_scores_gemma":[0.00001035894,0.00008813484,0.9980133,0.000005681592,0.0001283913,0.0002416598,0.0001303637,0.0008786604,0.0001272451,0.00009278794,0.000276776,0.000006635389],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979326,0.0001915792,0.0004414811,0.00006322926,0.000006675065,0.000011887,0.001117442,0.00001292469,0.0002222908],"genre_scores_gemma":[0.9985046,0.00007758027,0.0003083872,0.00003270642,0.000007648307,0.00001180042,0.0009093286,0.000003476873,0.0001445623],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004414535,"threshold_uncertainty_score":0.008777678,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01684988784671526,"score_gpt":0.3294158316775697,"score_spread":0.3125659438308544,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}