{"id":"W4417197094","doi":"10.3390/diagnostics15243144","title":"Histopathological Assessment of Cellular Heterogeneity in Pediatric Ependymomas","year":2025,"lang":"en","type":"article","venue":"Diagnostics","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Glial fibrillary acidic protein; Ependymoma; Immunohistochemistry; Histology; H&E stain; Transcriptome; Central nervous system; Pathological; Subependymal zone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007114012,0.0002742005,0.0001897465,0.003415711,0.0002822568,0.0004509092,0.0002659137,0.0002428695,0.001049547],"category_scores_gemma":[0.0006776488,0.0002067851,0.0001481026,0.0009677975,0.0004376453,0.000554334,0.0004713103,0.0002421109,0.0002015158],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003012194,"about_ca_system_score_gemma":0.0002644531,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006476701,"about_ca_topic_score_gemma":0.001364572,"domain_scores_codex":[0.999707,0.00003272929,0.00005393517,0.00007983526,0.00007836439,0.0000479897],"domain_scores_gemma":[0.9993048,0.0001292025,0.0002325847,0.00004555779,0.0001890554,0.00009885697],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005511293,0.00004221166,0.8098037,0.0002732753,0.000120846,0.00607789,0.0004997734,0.0004672186,0.1625872,0.000235648,0.0002501174,0.01909092],"study_design_scores_gemma":[0.00001391814,0.0001675173,0.9447002,0.00004141041,0.0001161516,0.01808884,0.0009279696,0.0009511184,0.03260565,0.0001550195,0.0022185,0.00001368213],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956177,0.001206361,0.001756755,0.00001725645,0.00000827473,0.00004528113,0.000223553,0.00002913922,0.001095546],"genre_scores_gemma":[0.9954866,0.0008004147,0.003013569,0.00001112862,0.00001093226,0.00003422924,0.0004225397,0.00001315581,0.000207384],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003415711,"threshold_uncertainty_score":0.003762245,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01825865755151844,"score_gpt":0.3187778495971437,"score_spread":0.3005191920456252,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}