{"id":"W4417197617","doi":"10.1128/aac.01482-25","title":"Drug susceptibility of a clinical isolate of <i>Balamuthia mandrillaris</i> , a pathogenic free-living amoeba","year":2025,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Legionella and Acanthamoeba research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Purdue Pharma (Canada)","funders":"National Research Council of Thailand; Mahidol University","keywords":"Drug; Amoeba (genus); Drug repositioning; Drug resistance; Antiseptic; Antibiotics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001237683,0.0002627769,0.0002463813,0.0001567744,0.0001832669,0.0002357745,0.0001776259,0.0002931248,0.0009836883],"category_scores_gemma":[0.0003056836,0.00009727473,0.0002165017,0.0001713046,0.0001157371,0.0001596138,0.0002149205,0.0003025058,0.0002888917],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001218661,"about_ca_system_score_gemma":0.0001239647,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002573191,"about_ca_topic_score_gemma":0.002084117,"domain_scores_codex":[0.9997181,0.00006017682,0.00005025368,0.00007129809,0.00005846728,0.00004161066],"domain_scores_gemma":[0.9998341,0.00003907468,0.00003262409,0.00001894931,0.00004486569,0.00003042152],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002636178,0.0001928426,0.007887127,0.00008674094,0.00001859681,0.0002483979,0.00008683679,0.00009316982,0.9882256,0.00002352655,0.0001237024,0.002749809],"study_design_scores_gemma":[0.00007138805,0.009512137,0.219701,0.00003810915,0.0001271312,0.004023791,0.0006769603,0.001885695,0.7595525,0.00004868693,0.004328724,0.00003385692],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998546,0.0003274287,0.0001588302,0.00002986737,0.00001266142,0.00002707254,0.0003457277,0.000009199609,0.0005432669],"genre_scores_gemma":[0.9968997,0.0002706969,0.0008244785,0.00004399926,0.000009408864,0.00002543113,0.001223643,0.000004999546,0.0006977247],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002573191,"threshold_uncertainty_score":0.005116403,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01252055488318059,"score_gpt":0.3081791196124022,"score_spread":0.2956585647292216,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}