{"id":"W4417197617","doi":"10.1128/aac.01482-25","title":"Drug susceptibility of a clinical isolate of <i>Balamuthia mandrillaris</i> , a pathogenic free-living amoeba","year":2025,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Legionella and Acanthamoeba research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Purdue Pharma (Canada)","funders":"National Research Council of Thailand; Mahidol University","keywords":"Drug; Amoeba (genus); Drug repositioning; Drug resistance; Antiseptic; Antibiotics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005234166,0.000157086,0.0003695959,0.00004909939,0.00006447914,0.00001542716,0.0002902806,0.0001841498,0.00003945346],"category_scores_gemma":[0.00007886878,0.0001373598,0.0002256567,0.0001353554,0.0002985487,0.000005133674,0.0002394674,0.0001249677,8.424996e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004659716,"about_ca_system_score_gemma":0.0001164096,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001427026,"about_ca_topic_score_gemma":0.0001001933,"domain_scores_codex":[0.9986107,0.0001160853,0.0005360241,0.0003972425,0.0001082546,0.0002317101],"domain_scores_gemma":[0.9991279,0.00004073857,0.0001676959,0.0004806497,0.0001224345,0.00006060367],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003060978,0.0003300315,0.3103179,0.0001658571,0.0001944088,0.000001649724,0.0001303188,0.000001700525,0.6595979,0.00003775931,0.02525608,0.003660232],"study_design_scores_gemma":[0.004797256,0.0004297832,0.4323931,0.0003382237,0.00008223941,0.000009606345,0.0001712661,0.0001460053,0.5188121,0.0002600954,0.04211196,0.0004483756],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979068,0.0001847316,0.0002471136,0.0006711097,0.0001434448,0.0002093647,0.00004558641,0.000006187821,0.0005856352],"genre_scores_gemma":[0.9935043,0.003551771,0.0003197499,0.001466499,0.00008745091,0.000002137892,0.0000152931,0.00001539142,0.001037444],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1407858,"threshold_uncertainty_score":0.5601372,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01252055488318059,"score_gpt":0.3081791196124022,"score_spread":0.2956585647292216,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}