{"id":"W4417199191","doi":"10.1038/s41586-025-09820-3","title":"Mapping the genetic landscape across 14 psychiatric disorders","year":2025,"lang":"en","type":"article","venue":"Nature","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Genome Canada; Centre for Addiction and Mental Health; University Health Network; Dalhousie University; University of Toronto; Hospital for Sick Children","funders":"National Institute of Mental Health; Canadian Institutes of Health Research; HORIZON EUROPE Framework Programme; Norges Forskningsråd; Novo Nordisk Fonden; National Institute for Health and Care Research; Novo Nordisk; National Institutes of Health; H. Lundbeck A/S; Lundbeckfonden; Regeneron Pharmaceuticals; National Alliance for Research on Schizophrenia and Depression; European Commission; Center for Individualized Medicine, Mayo Clinic; Autism Speaks","keywords":"Schizophrenia (object-oriented programming); Psychiatric genetics; Bipolar disorder; Comorbidity; Psychosis; Anxiety; Genetic association; Genetic correlation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00080506,0.0004342831,0.0004376224,0.002482473,0.0006558954,0.0006306298,0.0004501975,0.0005662336,0.001733309],"category_scores_gemma":[0.003061431,0.000220439,0.0007280958,0.003172983,0.0007717491,0.0002304096,0.001425778,0.0004635862,0.0001444279],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003903318,"about_ca_system_score_gemma":0.0004975819,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006097678,"about_ca_topic_score_gemma":0.008661835,"domain_scores_codex":[0.9980247,0.000499289,0.0001434802,0.0008969612,0.0002285054,0.0002069965],"domain_scores_gemma":[0.9982768,0.000789319,0.0005842245,0.0001123711,0.00008592397,0.00015139],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002651868,0.0000277574,0.969801,0.00007589944,0.0007060331,0.0007617098,0.0003260633,0.0007437363,0.014329,0.0003585141,0.0001531478,0.01245196],"study_design_scores_gemma":[0.0000123859,0.00007648229,0.9969534,0.00001191939,0.000152654,0.00076917,0.0001656719,0.0007441246,0.0004125409,0.0004205038,0.0002742316,0.000007010559],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978085,0.0004029483,0.00103414,0.00006026936,0.000002260867,0.00001070527,0.0004465112,0.00001146039,0.0002230882],"genre_scores_gemma":[0.9974655,0.0003098914,0.001222329,0.00004165381,0.000006968914,0.00001229888,0.0008615639,0.00000889109,0.00007081065],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006097678,"threshold_uncertainty_score":0.01212436,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004597158686183443,"score_gpt":0.2684395215181186,"score_spread":0.2638423628319351,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}