{"id":"W4417199674","doi":"10.70829/ijrmcs.v03.i02.005","title":"Translating Histopathology-Based AI Models into Clinical Tools for Homologous Recombination Deficiency Detection","year":2025,"lang":"","type":"article","venue":"International journal of research in medical and clinical science.","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hatch (Canada)","funders":"","keywords":"Ovarian cancer; Breast cancer; Homologous recombination; PARP inhibitor; Polymerase; Generalizability theory; Cancer; Poly ADP ribose polymerase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007926233,0.001387924,0.0005265202,0.001317211,0.0001889322,0.001195255,0.001210461,0.0008813835,0.003092279],"category_scores_gemma":[0.002420768,0.0005095151,0.001019226,0.0004355027,0.0002791103,0.0005671792,0.0008282618,0.00123462,0.001741459],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001068461,"about_ca_system_score_gemma":0.001139599,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0103115,"about_ca_topic_score_gemma":0.01462042,"domain_scores_codex":[0.9997818,0.00004428506,0.00001523635,0.0000774126,0.00004791038,0.00003332251],"domain_scores_gemma":[0.9994965,0.0002199663,0.00006023065,0.00004272655,0.0001415467,0.00003902957],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002806005,0.0002611579,0.0192232,0.0002326706,0.0002551159,0.0004106032,0.00006409264,0.6529272,0.008537996,0.002726999,0.01434474,0.3007357],"study_design_scores_gemma":[0.00000943681,0.00003954145,0.0009395144,0.00002696141,0.00002529644,0.00007476506,0.00001402869,0.9932156,0.001572886,0.002324,0.001747677,0.00001025726],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.09097359,0.003893226,0.8746625,0.002501088,0.0004928882,0.0004507817,0.005561917,0.01225077,0.009213247],"genre_scores_gemma":[0.7876211,0.00257593,0.1871797,0.001353147,0.0002861529,0.000610619,0.008798064,0.000586136,0.01098921],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.0103115,"threshold_uncertainty_score":0.02050292,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2045596982169754,"score_gpt":0.5814969070314854,"score_spread":0.37693720881451,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}