{"id":"W4417201075","doi":"10.1182/bloodadvances.2025016338","title":"Clinical characteristics, management, and hematopoietic cell transplantation of patients with TLR8 gain-of-function","year":2025,"lang":"en","type":"article","venue":"Blood Advances","topic":"Blood disorders and treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital","funders":"AstraZeneca; Genentech; National Cancer Institute; National Institutes of Health; Swedish Orphan Biovitrum; Children's Discovery Institute","keywords":"Pure red cell aplasia; Cytopenia; Bone marrow failure; Myeloid; Disease; Hematopoietic stem cell transplantation; Bone marrow; Transplantation; Immune system; Aplastic anemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001960777,0.0003160197,0.0002599204,0.000432043,0.0003133373,0.0002566396,0.000166506,0.0003785049,0.000903427],"category_scores_gemma":[0.0009974641,0.00008072687,0.0001387126,0.0002461437,0.0002138839,0.0002113843,0.0001761601,0.0003256075,0.0001927057],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001686135,"about_ca_system_score_gemma":0.0001667916,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002806575,"about_ca_topic_score_gemma":0.0002897807,"domain_scores_codex":[0.9998389,0.00003105922,0.00002121277,0.00003768675,0.00002969251,0.0000414165],"domain_scores_gemma":[0.9996051,0.00009409953,0.0001138828,0.00001112597,0.00002842249,0.0001472225],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002361829,0.00006932907,0.9701651,0.00001538048,0.00002394626,0.01600165,0.0001480157,0.0001932088,0.004761102,0.00006907267,0.0004132674,0.007903867],"study_design_scores_gemma":[0.00004551364,0.0008586672,0.8237811,0.00002699017,0.0000404965,0.1715692,0.0003048672,0.0008389166,0.001480599,0.0001217976,0.0009166565,0.00001515427],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998881,0.0002632406,0.000119212,0.00007875841,0.0000045908,0.000007181921,0.00005670885,0.000005853205,0.0005834068],"genre_scores_gemma":[0.9995192,0.00007420834,0.0001225377,0.00005786587,0.00001775494,0.000006788217,0.0001101007,0.000002049341,0.00008942463],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000903427,"threshold_uncertainty_score":0.003022254,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003467437545169783,"score_gpt":0.2343120333167124,"score_spread":0.2308445957715426,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}