{"id":"W4417201213","doi":"10.1158/1557-3265.earlyonsetca25-pr001","title":"Abstract PR001: Risk prediction modeling for colorectal adenomas in persons under age 50: a risk-stratified approach to early onset colorectal cancer prevention","year":2025,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Colorectal Cancer Screening and Detection","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Colorectal cancer; Colonoscopy; Cohort; Area under the curve; Incidence (geometry); Cohort study; Disease; Predictive value","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003255953,0.000945797,0.0009453705,0.00114888,0.000329823,0.001321931,0.001249138,0.0008559456,0.004731734],"category_scores_gemma":[0.008562139,0.0003697336,0.002393556,0.0005798715,0.0002110935,0.0004552332,0.0009832835,0.001496125,0.0007837561],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005251482,"about_ca_system_score_gemma":0.001171504,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01005489,"about_ca_topic_score_gemma":0.005675729,"domain_scores_codex":[0.9992464,0.0004150661,0.00004418374,0.0001645676,0.00007092558,0.00005892635],"domain_scores_gemma":[0.9973963,0.001724792,0.0002805894,0.0001332118,0.0003216857,0.000143294],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.002740706,0.001013924,0.5279126,0.0005313813,0.002286318,0.0007926318,0.0003031442,0.323352,0.001751866,0.004148278,0.01424885,0.1209182],"study_design_scores_gemma":[0.000111309,0.0005517043,0.03244815,0.0001174093,0.0004570155,0.0002593729,0.0001042928,0.9604362,0.0003108437,0.003327049,0.001842638,0.0000340889],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7515858,0.002210866,0.2254017,0.005203184,0.0003848879,0.0007974194,0.008444577,0.001387211,0.004584381],"genre_scores_gemma":[0.9568902,0.0005007017,0.03669509,0.0003087436,0.0001653405,0.0003021215,0.002932713,0.0000619525,0.00214326],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01005489,"threshold_uncertainty_score":0.01999271,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1994804513974486,"score_gpt":0.4839151851797938,"score_spread":0.2844347337823451,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}